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Dr Harprit Singh

Job: Associate Professor - Research/Reader

Faculty: Health and Life Sciences

School/department: School of Allied Health Sciences

Address: De Montfort University, The Gateway, Leicester, LE1 9BH.

T: +44 (0)116 257 7779

E: harprit.singh@dmu.ac.uk

W: https://www.dmu.ac.uk/research/centres-institutes/iahsr/index.aspx

 

Personal profile

Associate Professor/Reader with research interests in the field of Metabolic disease  and Vascular cell signalling. Support teaching for the following programmes:

  • Biomedical Science
  • Adv Biomedical Science
  • Medical Science

Research group affiliations

Key research outputs

  • Tahir T.A, Singh H and Brindle NPJ. The RNA Binding Protein hnRNP-K Mediates Post -Transcriptional Regulation of Uncoupling Protein-2 by Angiopoietin-1. Cellular Signalling. 2014 26 (7) 1379-1384
  • Singh H, Hansen T, Patel N, and Brindle NPJ. The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNF and regulates Angiopoietin signalling.   PLoS ONE.  2012 7  (1) doi: 10.1371/journal.pone.0029319
  • Singh H, Tahir TA, Alawo DO, Issa E and Nicholas PJ Brindle. Molecular control of Angiopoietin signalling. Biochem Soc Trans. 2011 39 (6) 1592-1596
  • Singh H, Brindle NPJ, and Zammit VA. High glucose and elevated fatty acids suppress signalling by the endothelium protective ligand Angiopoietin-1. Microvascular Research. 2010 79 (2) 121-127
  • Singh H, Milner CS, Aguilar-Hernandez M, Patel N, and Brindle NPJ. Vascular endothelial growth factor activates the Tie family of receptor tyrosine kinases. Cellular signalling. 2009 21 (8) 1346-1350 (Faculty of 1000 biology recommendation)

Research interests/expertise

Involved in investigating the mechanism associated with metabolic syndrome induced endothelial dysfunction and cardiovascular disease in patients. Research expertise includes:

  • Cardiovascular Disease
  • Diabetes
  • Endothelial biology
  • Cell signalling
  • Growth hormones and their Receptors.
  • Molecular markers of vascular disease
  • Translational research

Areas of teaching

  • Endocrinology
  • Cardiovascular 
  • Human Anatomy and Physiology
  • Angiogenesis

Qualifications

  • PhD in Biochemistry
  • PGCert in Teaching and Learning in Higher Education
  • BSc (Hons) Medical Biochemistry

Courses taught

  • Medical Science (BMed Sci)
  • Biomedical Science (BSc)
  • Adv Biomedical Science (MSc)

Honours and awards

  • Fellow of the Higher Education Academy (FHEA)

Membership of professional associations and societies

  • The British Society for Cardiovascular Research
  • European Society of Cardiology Working Group Atherosclerosis & Vascular Biology

Conference attendance

  • Angiopoietin 1 signalling, a marker of endothelial dysfunction in patients with coronary artery disease. 23-24 April 2012. Leicester.  4th British Pharmacological Society. Harprit Singh.
  • The molecular balance between receptor tyrosine kinases TIE1 and TIE2 is dynamically controlled by diverse agonists and regulates responsiveness of TIE2 to its ligand. 8-10 June 2011, University of Edinburgh, UK. Signalling 2011: Biochemical Society Centenary Conference, Harprit Singh. Oral presentation.

Key articles information

[Add key research outputs information here] 

e.g ‘Outputs, e.g. selected publications’ produced since January 2008

Current research students

  • Joseph Festa, PhD
  • Koddus Ali, PhD
  • Nasrin Shokrzadeh, PhD 
  • Tam Nqoc Minh Vu, PhD

Externally funded research grants information

  • NIHR-CARDIOVASCULAR BIOMEDICAL RESEARCH UNIT (2011) “Angiopoietin 1 signalling in endothelial cells isolated from patients with vascular disease”.
  • VIP WELLCOME TRUST RESEARH FELLOW (2009) “Effect of Metabolic syndrome on Angiopoietin 1 signalling in endothelial cells”.
     

Internally funded research project information

  • The Effect of Diabetes on Angiopoietin 1 Signalling in the development of Vascular Disease. DMU Graduate School Full Bursary PhD Scholarship. 2016-2020.
  • Micro-bead technology in the purification of human coronary endothelial cells, Research Investment Fund 7, June 2015-July 2016, PI. 

Potential PhD projects for students

  • Diabetes and Endothelial signalling
  • Impact of Polyunsaturated fat on Endothelial signalling
  • Predicting vascular disease

Successfully Supervised PhD Students

 Jay Bilimoria, 2016-2020

Aamir Hussain, 2015-2019

 Rasmieh Alziedan, 2012-2016

 

Journal Peer Reviewer

  • Journal of Biomedical Research
  • Cancer Letters
  • Human Cell

Grant Peer Reviewer

Medical Research Council