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Dr Harprit Singh

Job: Senior Lecturer in Medical Science

Faculty: Health and Life Sciences

School/department: School of Allied Health Sciences

Address: De Montfort University, The Gateway, Leicester, LE1 9BH.

T: +44 (0)116 257 7779

E: harprit.singh@dmu.ac.uk

W: dmu.ac.uk/beh

 

Personal profile

Senior Lecturer in Medical Science with research interests in the field of diabetes and cardiovascular research. Support teaching for the following programmes:

  • Biomedical Science
  • Medical Science

Research group affiliations

Publications and outputs 


Click here to view a full listing of Dr Harprit Singh's publications and outputs 

Key research outputs

  • Tahir T.A, Singh H and Brindle NPJ. The RNA Binding Protein hnRNP-K Mediates Post -Transcriptional Regulation of Uncoupling Protein-2 by Angiopoietin-1. Cellular Signalling. 2014 26 (7) 1379-1384
  • Singh H, Hansen T, Patel N, and Brindle NPJ. The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNF and regulates Angiopoietin signalling.   PLoS ONE.  2012 7  (1) doi: 10.1371/journal.pone.0029319
  • Singh H, Tahir TA, Alawo DO, Issa E and Nicholas PJ Brindle. Molecular control of Angiopoietin signalling. Biochem Soc Trans. 2011 39 (6) 1592-1596
  • Singh H, Brindle NPJ, and Zammit VA. High glucose and elevated fatty acids suppress signalling by the endothelium protective ligand Angiopoietin-1. Microvascular Research. 2010 79 (2) 121-127
  • Singh H, Milner CS, Aguilar-Hernandez M, Patel N, and Brindle NPJ. Vascular endothelial growth factor activates the Tie family of receptor tyrosine kinases. Cellular signalling. 2009 21 (8) 1346-1350 (Faculty of 1000 biology recommendation)

Research interests/expertise

Involved in investigating the mechanism associated with metabolic syndrome induced endothelial dysfunction and cardiovascular disease in patients. Research expertise includes:

  • Cardiovascular Disease
  • Diabetes
  • Endothelial biology
  • Cell signalling
  • Growth hormones and their Receptors.
  • Molecular markers of vascular disease
  • Translational research

Areas of teaching

  • Endocrinology
  • Cardiovascular 
  • Human Anatomy and Physiology
  • Personal and Professional skills

Qualifications

  • PhD in Biochemistry
  • PGCert in Teaching and Learning in Higher Education
  • BSc (Hons) Medical Biochemistry

Courses taught

  • Medical Science (BMed Sci)
  • Biomedical Science (BSc)

Honours and awards

  • Fellow of the Higher Education Academy (FHEA)

Membership of professional associations and societies

  • The British Society for Cardiovascular Research

Conference attendance

  • Angiopoietin 1 signalling, a marker of endothelial dysfunction in patients with coronary artery disease. 23-24 April 2012. Leicester.  4th British Pharmacological Society. Harprit Singh.
  • The molecular balance between receptor tyrosine kinases TIE1 and TIE2 is dynamically controlled by diverse agonists and regulates responsiveness of TIE2 to its ligand. 8-10 June 2011, University of Edinburgh, UK. Signalling 2011: Biochemical Society Centenary Conference, Harprit Singh. Oral presentation.

Current research students

  • Jay Bilimoria, PhD, 1st Supervisor 
  • Tam Nqoc Minh Vu, PhD, 2nd Supervisor

Externally funded research grants information

  • NIHR-CARDIOVASCULAR BIOMEDICAL RESEARCH UNIT (2011) “Angiopoietin 1 signalling in endothelial cells isolated from patients with vascular disease”.
  • VIP WELLCOME TRUST RESEARH FELLOW (2009) “Effect of Metabolic syndrome on Angiopoietin 1 signalling in endothelial cells”.
     

Internally funded research project information

Micro-bead technology in the purification of human coronary endothelial cells, Research Investment Fund 7, June 2015-July 2016, PI. 

Potential PhD projects for students

  • Diabetes and Endothelial signalling
  • Impact of Polyunsaturated fat on Endothelial signalling
  • Predicting vascular disease

Successfully Supervised PhD Students

 Rasmieh Alziedan, 2012-2016

Journal Peer Reviewer

  • Journal of Biomedical Research
  • Cancer Letters

Grant Peer Reviewer

Medical Research Council

Harprit-Singh

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