Book Chapter on TVIS submitted for Springer Publication

Chapter submitted for publication in a book by Springer (New York)  entitled  “Lyophilization of Pharmaceuticals and Biologicals : New Technologies and Approaches”, edited by Kevin Ward (Biopharma) and  Paul Matejtschuk (NIBSC) . The book is in the series “Methods in Pharmacology & Toxicology” and the chapter is titled : “Through vial impedance spectroscopy (TVIS): A novel approach to process understanding for freeze-drying cycle development” and describes the fundamental basis of the TVIS technology, including a description of the measurement system that was developed by Evgeny Polygalov as the first prototype instrument, and the physical origins of the dielectric loss processes associated with the Maxwell-Wagner charging of the glass wall capacitance of the freeze-drying vial when the contents of the vial are in the liquid state and the dielectric relaxation of ice when the contents of the vial are in the frozen (solid) state.