Horley NJ, Beresford KJ, Kaduskar S, Joshi P, McCann GJ, Ruparelia KC, Williams I, Gatchie L, Sonawane VR,, Bharate SS, Chaudhuri B. (E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent. Bioorg. Med. Chem. Lett. (2017) Vol. 27, pp 5409-5414. DOI: 10.1016/j.bmcl.2017.11.009
Mohd Siddique MU, McCann GJ, Sonawane VR, Horley N, Gatchie L, Joshi P, Bharate SB, Jayaprakash V, Sinha BN, Chaudhuri B. (2017) Quinazoline derivatives as selective CYP1B1 inhibitors. Eur J Med Chem. 2017 Apr 21;130:320-327. doi: 10.1016/j.ejmech.2017.02.032. Epub 2017 Feb 16
Horley NJ, Beresford KJ, Chawla T, McCann GJ, Ruparelia KC, Gatchie L, Sonawane VR, Williams IS, Tan HL, Joshi P, Bharate SS, Kumar V, Bharate SB, Chaudhuri B.(2017) Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming
cisplatin resistance in CYP1B1-overexpressing lines. Eur J Med Chem. 2017 Mar 31;129:159-174. doi: 10.1016/j.ejmech.2017.02.016. Epub 2017 Feb 9.
Mohd Siddique MU, McCann GJ, Sonawane V, Horley N, Williams IS, Joshi P, Bharate SB, Jayaprakash V, Sinha BN, Chaudhuri B (2016) Biphenyl urea derivatives as selective CYP1B1 inhibitors. Org Biomol Chem. 2016 Sep 26;14(38):8931-8936.
Stabilisation Chaudhuri, Horley, McCann, Biboy (2010) UK Patent WO2010010343 A1. Filing date 22/07/2009
Al-Anizy M, Horley NJ, Kuo CW, Gillett LC, Laughton CA, Kendall D, Barrett DA, Parker T, Bell DR. (2006) Cytochrome P450 Cyp4x1 is a major P450 protein in mouse brain. FEBS J. 2006 Mar; 273(5):936-47.
Jeffery B, Choudhury AI, Horley N, Bruce M, Tomlinson SR, Roberts RA, Gray TJ, Barrett DA, Shaw PN, Kendall D, Bell DR. (2004) Peroxisome proliferator activated receptor alpha regulates a male- specific cytochrome P450 in mouse liver. Arch Biochem Biophys. 2004 Sep 15; 429(2):231-6.
Choudhury AI, Sims HM, Horley NJ, Roberts RA, Tomlinson SR, Salter AM, Bruce M, Shaw PN, Kendall D, Barrett DA, Bell DR. (2004) Molecular analysis of peroxisome proliferation in the hamster. Toxicol Appl Pharmacol. 2004 May 15; 197(1):9-18.
N.J. Plant, N.J. Horley, C.R. Elcombe, D.R. Bell (1998). The coordinate regulation of DNA synthesis and suppression of apoptosis is differentially regulated the liver growth agents, phenobarbital and methylclofenapate. Carcinogenesis 19: 1521-1527
N.J. Plant, N.J. Horley, R.L. Savory, C.R. Elcombe, T.J.B. Gray and D.R. Bell (1998). The peroxisome proliferators are hepatocyte mitogens in chemically-defined media: glucocorticoid-induced PPARα is linked to peroxisome proliferator mitogenesis. Carcinogenesis 19: 925-934.
A.R. Bell, R. Savory, N.J. Horley, A.I. Choudhury, M. Dickins, T.J.B. Gray, A.M. Salter and D.R. Bell (1998). Molecular basis of non-responsiveness to peroxisome proliferators: The guinea pig PPARα is functional and mediates peroxisome proliferator-induced hypolipidaemia. Biochemical Journal 332: 689-693.
D.R. Bell, N.J. Plant, N.J. Horley, C.R. Elcombe (1996). Peroxisome proliferators induce high levels of DNA synthesis in primary cultures of rat hepatocytes. Annals of the New York Academy of Sciences 804: 745-746.
N.J. Plant, N.J. Horley, M. Dickins, D.R. Bell. Peroxisome proliferators induce DNA synthesis in primary cultures of rat hepatocytes. Abstract submitted to the 6th Stowe Symposium on Drug Metabolism: July 1996.
B.J.Leckie and N.J. Horley. Cloning of potassium channel subunits from human aortic cDNA. Abstract submitted to the 16th scientific meeting of the International Society of Hypertension (Glasgow): June 1996.
N.J. Horley, N.J. Plant, D.R. Bell. Peroxisome proliferators induce DNA synthesis in primary cultures of rat hepatocytes. Abstract submitted to the Hepatocyte User Group (HUG) Meeting (Amsterdam): September 1994.