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Through Vial Impedance Spectroscopy

Through Vial Impedence Spectroscopy (TVIS)


Through Vial Impedence Spectroscopy (TVIS)


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Through Vial Impedance Spectroscopy (TVIS)

Through-vial impedance spectroscopy (TVIS) is a novel process analytical technology for monitoring and/or controlling the freeze-drying of pharmaceutical products.

The technology was developed by Geoff Smith and Evgeny Polygalov at De Montfort University, in collaboration with a number of industrial partners (GEA Pharma Systems, BlueFrog Design, Onkolytika, Sanofi: Ireland) and the National Institute for Biological Standards and Control (NIBSC).

The development of through vial impedance spectroscopy (TVIS) marks the first time that impedance spectroscopy has been used to characterise materials within conventional glass freeze-drying vials, without having to insert the electrodes into the product (i.e. the solution under-going freeze-drying). This feature of the technology sets it apart form other systems on the market in which a bulky electrode is inserted to the solution being freeze-dried.


TVIS enables non-invasive, real time, in-line monitoring of the lyophilisation process, leading to increased process understanding and accelerated product development, especially in relation to the development of room temperature stabilised biopharmaceutical formulations.

For further information contact:

Prof. Geoff Smith
Pharmaceutical Technologies Group
Leicester School of Pharmacy
De Montfort University

T: +44 (0)116 250 6298




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