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Professor Martin Grootveld

Job: Professor of Bioanalytical Chemistry and Chemical Pathology

Faculty: Health and Life Sciences

School/department: Leicester School of Pharmacy

Research group(s): Biomedical & Environmental Health

Address: De Montfort University, The Gateway, Leicester, LE1 9BH.

T: +44 (0)116 250 6443

E: mgrootveld@dmu.ac.uk

W: www.dmu.ac.uk/pharmacy

 

Personal profile

After first graduating in Chemistry/Statistical Analysis at Birkbeck College, University of London in 1981 (achieved part-time whilst employed as a scientific officer at Guy’s Hospital Poisons Unit), Prof. Grootveld completed his PhD degree research programme on bioanalytical chemistry and metallodrugs in 1985 at the same institution and then conducted post-doctoral work on the analysis of ‘markers’ of free radical activity in biofluids at King’s College, University of London for 2 years. He then spent 2.5 years lecturing and conducting research work at the Polytechnic of North London prior to taking up a Lectureship in Clinical Chemistry at St. Bartholomews and the Royal London School of Medicine and Dentistry in 1989, where he subsequently became Senior Lecturer and then Reader in Chemical Pathology. Later, he transferred to London South Bank University where he was also Reader in Chemical Pathology, and Director of their MSc Forensic Science course. He was then appointed Professor of Chemical Pathology and Biomedical Materials at the Institute for Materials Research and Innovation (IMRI), University of Bolton where he established and directed a Master’s course in Medical and Healthcare Devices which was the first of its kind available in the UK. Recently, he took up the postion of Professor of Bioanalaytical Chemistry at Leicester School of Pharmacy, De Montfort University, where he is also Head of the Medicinal Chemistry Group. He was Visiting Professor of Clinical Chemistry at Queen’s University Belfast from 2001-2005. Prof. Grootveld is the author of 108 full, refereed research publications in reputable international scientific and/or clinical journals, 17 reviews and more than 200 refereed conference contributions. Since 1987, he has attracted more than £5,700,000 of external research funding.

Prof. Grootveld is a Fellow of the Society of Biology and the Royal Society of Chemistry, and is also a Member of the Institute of Biomedical Sciences and the European Tooth-Whitening Committee. He also organised and chaired the very first international symposium regarding the applications of high-resolution NMR techniques to the oral science area (IADR conference, New Orleans, USA, March 2007). His administrative duties have included student recruitment, budget and policy issues, together with successful programme development. He has recently been appointed to the position of Honorary Associate Clinical Professor at Warwick Medical and Dental School, University of Warwick for a 3-year period.

Research activities: Attraction of research funding from research councils, EU, medical charities, industrial sources, etc.; operation and management of such externally-funded research programmes; publication of research data in reputable scientific/clinical journals; supervision of post-doctoral and postgraduate staff; generation and management of research  grant research outputs.   

Research group affiliations

Biomedical & Environmental Health|

Medicinal Chemistry

Bioanalytical Chemistry

Pharmacology |

Publications and outputs 

Click here to view a full listing of Martin Grootveld's publications and outputs.|

Research interests/expertise

  • Biomolecular investigations of the aetiology and pathogenesis of inflammatory and cardiovascular diseases;
  • The role of ‘oxidative stress’ in the pathogenesis of human diseases;
  • The multicomponent high-resolution NMR analysis of biofluids and tissues for diagnostic, prognostic and forensic purposes;
  • Biomedical, bioanalytical and metabolomic investigations of oral diseases and the therapeutic activities of oral healthcare products;
  • The development and application of techniques for the monitoring of drugs of both clinical and forensic interest;
  • Synthesis, applications and mechanisms of action of drugs and metallodrugs;
  • Pharmacology and pharmacodynamics (both clinical and forensic aspects);
  • The biological and medicinal chemistry of reactive oxygen species (ROS), together with the detection and pathological significance of products derived from their reactions, both in vitro and in vivo;
  • Biological inorganic chemistry, for example the ‘speciation’ of metal ions in biofluids and tissues;
  • The development and testing of novel biomaterials and biosensors;
  • Bio- and chemometrics, and metabolomics, including NMR-based exploratory data analysis and pattern recognition techniques;
  • Design, development and testing of metal alloy oral and joint prostheses;
  • The experimental design of clinical trials and statistical analysis of data derived therefrom;
  • Research ethics of clinical investigations.

Areas of teaching

Delivery of lectures on Clinical Trials, Statistical Analysis of Experimental Data, Chemical Pathology, Bioanalytical and Analytical Chemistry, and Biomedical Materials; Module Leader for Forensic Science Module ‘Molecules Have Fingerprints Too’.

Qualifications

BSc, PhD, MIBMS, CBiol, FSB, FRSC

Courses taught

BSc Forensic Science (Molecules have Fingerprints Too)

Honours and awards

  • Prof. Grootveld is the author of 109 full, refereed research publications in reputable international scientific and/or clinical journals, 17 reviews and more than 200 refereed conference contributions. Since 1987, he has attracted more than £5,700,000 of external research funding.
  • Honorary Associate Clinical Professor at Warwick Medical and Dental School, University of Warwick for a 3-year period.
  • Visiting Professor of Clinical Chemistry at Queen’s University Belfast from 2001-2005.
  • Organised and chaired the very first international symposium regarding the applications of high-resolution NMR techniques to the oral science area (IADR conference, New Orleans, USA, March 2007).

Membership of external committees

Member of the European Tooth-Whitening Committee.

Membership of professional associations and societies

  • Fellowship of the Society of Biology and the Royal Society of Chemistry.
  • Member of the Institute of Biomedical Sciences.

Conference attendance

More than 200 refereed conference contributions.

Consultancy work

Consultant for a very wide range of healthcare, oral healthcare, pharmaceutical and food companies/corporation.

Current research students

Currently 8 PhD students (5 as Director of Studies, 3 as Second Supervisor).

Externally funded research grants information

Grant Holder(s)

Funding Body

Period of Award

Amount

Title of Project

Grootveld, M. (with M.  Miraftab).

University of Bolton

2010-2013

£60K

PhD Studentship: Design and Development of (1) The Next Generation of Prosthetic Veins and Arteries and (2) Biomarker Sensors for Application in Cardiovascular Diseases

Grootveld, M.  (with M.

Henriques, G. M. B. Soares )  

 

 

 

Fundaco para a Ciencia e a Tecnologia (FCT)

 

2009-2013

€75K 

Development of a New Anti-Microbial Fabric for Wound Dressings

Grootveld, M.

HEIF_5 Award

2013

£13.8K

Design and Formulation of Novel, Dual-Compartment, Non-Erosive Tooth-Whitening Products which Generate Chlorine Dioxide In Situ

Grootveld, M. (with R Arroo):

HEIF_5 Award

2013-2014

£30K

Establishment and Development of a Novel, Commercially-Viable Analytical/Bioanalytical Service System at Leicester School of Pharmacy. 

Grootveld, M.

UK and EU Industry: Healthcare Corporations

2013-2015

£40K

Metabolomic Investigations of the Therapeutic Actions of Oral Healthcare Products

Internally funded research project information

Grant Holder(s)

Funding Body

Period of Award

Amount

Title of Project

Grootveld, M. (with R. Prasad and A. Farooqui).

 

DMU RCIF Award

2012-2013

£30K

Spectroscopy-Linked Multivariate Chemometric Investigations of Chronic Obstructive Pulmonary Disease (COPD) in Leicester.

Grootveld, M. (with D. Sillence).

 

 

DMU FHLS SMALL PROJECTS SCHEME

2013

£5K

Metabolic Classification of Niemann-Pick Type C1 Disease.

Grootveld, M. (with D. Sillence, D.Elizondo and F. Platt)

 

DMU FEES-ONLY SCHOLARSHIP AWARD

2013-2016

£12.4K

Development of Novel Strategies for the Analysis of Multivariate 1H NMR Datasets

Grootveld, M.  (with K. Huddersman and E. Jaroszkiewicz)

CARTER-GUNN FELLOWSHIP AWARD

2013

£8K

γ-Irradiation Sterilisation of Drugs

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