Targeting pneumococcal carbohydrate metabolism to treat childhood infections. Funded by Rosetrees Trust (PI, June 2018-2020). Investigation of chemically-modified galactose analogues as novel treatments for Streptococcus pneumoniae biofilm-associated infections.
Investigation of non-typeable Haemophilus influenzae (NTHi) biofilm infection in Primary Ciliary Dyskinesia. 2 PhD studentships funded by Wessex Medical Research, Southampton NIHR Biomedical Research Centre, and Asthma, Allergy & Inflammation Research Charity (CI, Oct 2018-2021). Development of a new model incorporating NTHi, primary respiratory epithelial cells, and macrophages to investigate host-pathogen interactions and biofilm clearance using novel nitric oxide donor compounds.
Investigation into the role of epithelial lipid membrane profiles in bacterial colonisation. Funded by British Lung Foundation (CI, July 2019-2021). Investigation into how the lipid membrane profile of respiratory epithelium is linked to Pseudomonas aeruginosa colonisation and biofilm formation in Cystic Fibrosis.