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Professor Martin Grootveld

Job: Professor of Bioanalytical Chemistry and Chemical Pathology

Faculty: Health and Life Sciences

School/department: Leicester School of Pharmacy

Research group(s): Biomedical & Environmental Health

Address: De Montfort University, The Gateway, Leicester, LE1 9BH.

T: +44 (0)116 250 6443

E: mgrootveld@dmu.ac.uk

W: https://www.dmu.ac.uk/pharmacy

 

Personal profile

After first graduating in Chemistry/Statistical Analysis at Birkbeck College, University of London in 1981 (achieved part-time whilst employed as a scientific officer at Guy’s Hospital Poisons Unit), Prof. Grootveld completed his PhD degree research programme on bioanalytical chemistry and metallodrugs in 1985 at the same institution and then conducted post-doctoral work on the analysis of ‘markers’ of free radical activity in biofluids at King’s College, University of London for 2 years. He then spent 2.5 years lecturing and conducting research work at the Polytechnic of North London prior to taking up a Lectureship in Clinical Chemistry at St. Bartholomew’s and the Royal London School of Medicine and Dentistry in 1989, where he subsequently became Senior Lecturer and then Reader in Chemical Pathology. Later, he transferred to London South Bank University where he was also Reader in Chemical Pathology, and Director of their MSc Forensic Science course. He was then appointed Professor of Chemical Pathology and Biomedical Materials at the Institute for Materials Research and Innovation (IMRI), University of Bolton where he established and directed a Master’s course in Medical and Healthcare Devices which was the first of its kind available in the UK. Recently, he took up the position of Professor of Bioanalytical Chemistry at Leicester School of Pharmacy, De Montfort University, where he is also Head of the Chemistry for Health/Bioanalytical Sciences Research Group. He was Visiting Professor of Clinical Chemistry at Queen’s University Belfast from 2001-2005. Prof. Grootveld is the author of more than 160 full, peer-reviewed research publications in reputable international scientific and/or clinical journals, 25 reviews/book chapters, and more than 250 refereed conference contributions. He is also the Editor and author of 4 books. Since 1987, he has attracted more than £8,000,000 of external research funding. In 2020 alone, Prof. Grootveld achieved 20 full-length research publications in reputable scientific or clinical journals, along with 4 reviews and 1 edited/authored book. Prof. Grootveld was the very first researcher to apply non-stationary, low-field benchtop nuclear magnetic resonance (NMR) facilities to the multicomponent analysis of biological fluids such as human urine as early as 2014, which was long before anyone else had attempted to claim or exploit this development.  

Prof. Grootveld is a Fellow of the Royal Society of Biology, the Royal Society of Chemistry, and the Institute of Biomedical Sciences. He is also a Fellow of the Royal Statistical Society. His is also a member of the Editorial Board of the highly-prestigious MDPI journal Metabolites, and is currently serving as a lead guest Editor for Frontiers in Nutrition. He organised and the very first international symposium regarding the applications of high-resolution NMR techniques to the oral science area (IADR conference, New Orleans, USA, March 2007). His administrative duties have included student recruitment, budget and policy issues, together with successful programme development. Previously, he also held the position of Honorary Associate Clinical Professor at Warwick Medical and Dental School, University of Warwick for a 3-year period. Prof. Grootveld was also shortlisted as one of the top 5 PhD supervisors in the whole of the UK by FindAUniversity Ltd. in 2020.

Research activities: Attraction of research funding from research councils, EU, medical charities, industrial sources, etc.; operation and management of such externally-funded research programmes; publication of research data in reputable scientific/clinical journals; supervision of post-doctoral and postgraduate staff; generation and management of research grant research outputs.

Research group affiliations

Biomedical & Environmental Health

Medicinal Chemistry

Bioanalytical Chemistry

Pharmacology

Research interests/expertise

  • Biomolecular investigations of the aetiology and pathogenesis of inflammatory and cardiovascular diseases;
  • The role of ‘oxidative stress’ in the pathogenesis of human diseases;
  • The multicomponent high-resolution NMR analysis of biofluids and tissues for diagnostic, prognostic and forensic purposes;
  • Biomedical, bioanalytical and metabolomic investigations of oral diseases and the therapeutic activities of oral healthcare products;
  • The development and application of techniques for the monitoring of drugs of both clinical and forensic interest;
  • Synthesis, applications and mechanisms of action of drugs and metallodrugs;
  • Pharmacology and pharmacodynamics (both clinical and forensic aspects);
  • The biological and medicinal chemistry of reactive oxygen species (ROS), together with the detection and pathological significance of products derived from their reactions, both in vitro and in vivo;
  • Biological inorganic chemistry, for example the ‘speciation’ of metal ions in biofluids and tissues;
  • The development and testing of novel biomaterials and biosensors;
  • Bio- and chemometrics, and metabolomics, including NMR-based exploratory data analysis and pattern recognition techniques;
  • Design, development and testing of metal alloy oral and joint prostheses;
  • The experimental design of clinical trials and statistical analysis of data derived therefrom;
  • Research ethics of clinical investigations.

Areas of teaching

Delivery of lectures on Clinical Trials, Statistical Analysis of Experimental Data, Chemical Pathology, Bioanalytical and Analytical Chemistry, and Biomedical Materials; Module Leader for Forensic Science Module ‘Molecules Have Fingerprints Too’.

Qualifications

  • Fellowship of the Royal Society of Chemistry
  • Fellowship of the Society of Biology
  • Chartered Biologist
  • Fellowship of the Institute of Biomedical Sciences
  • Fellowship of the Royal Statistical Society.

Courses taught

BSc Forensic Science (Molecules have Fingerprints Too)

Honours and awards

  • Prof. Grootveld is the author of 109 full, refereed research publications in reputable international scientific and/or clinical journals, 17 reviews and more than 200 refereed conference contributions. Since 1987, he has attracted more than £5,700,000 of external research funding.
  • Honorary Associate Clinical Professor at Warwick Medical and Dental School, University of Warwick for a 3-year period.
  • Visiting Professor of Clinical Chemistry at Queen’s University Belfast from 2001-2005.
  • Organised and chaired the very first international symposium regarding the applications of high-resolution NMR techniques to the oral science area (IADR conference, New Orleans, USA, March 2007).

Membership of external committees

Member of the European Tooth-Whitening Committee.

Membership of professional associations and societies

  • Fellowship of the Society of Biology and the Royal Society of Chemistry.
  • Member of the Institute of Biomedical Sciences

Conference attendance

More than 200 refereed conference contributions.

Consultancy work

Consultant for a very wide range of healthcare, oral healthcare, pharmaceutical and food companies/corporation.

Current research students


Student

 

Mode 

     


Supervisory Status
    

     

University                  

 Dates 

                                Project Title             

          Current Status  
Vijay

F/T

Second University of Bolton

06/11-06/15

Design and Development of (1) the Next Generation of Prosthetic Veins and  Arteries and (2) Biomarker Sensors for Application in Cardiovascular Diseases Thesis to be submitted shortly
Andras Weber

F/T

First University of Bolton

03/10-12/15

1H NMR-Linked Targeted Metabolomics Investigations of Human Saliva  Thesis to be submitted shortly
Omer Aziz

F/T

First De Montfort University 

04/12-04/15

An Exploration of the Practice of Prescribing and Use of Medicines, with a Special Focus on Self-Medication Practices in the Context of Developing Reform within the Healthcare System in Kurdistan-Iraq In progress (nearing completion)
Victor Ruiz Rodado

F/T

First De Montfort University 

09/13-08/16

New Developments in 1H NMR-linked Metabolomics: Identification of New Bi8omarkers for the Prognostic Stratification of Hodgkin's Lympoma and the Metabolomic Classification of Niemann-Pick Disease Class C In progress (nearing completion)
Pushpa Upreti

F/T

Second De Montfort University  09/12-09/15 Modified Polyacrylonitrile (PAN) Catalyst for the Oxidative Decomposition of  Organic Pollutants in  Wastewater In progress
Mamadou Bamba

F/T

First De Montfort University 01/14-01/17 Development and Application of Novel Computational Intelligence Techniques (CITs) to the Multivariate Analysis of Metabolomic Biofluid and Phytochemical Datasets  In progress
Tracey Lennemann

P/T

First De Montfort University 03/14-03/18 Sustainable Delivery Methods for (‘Grass-Roots’) Oral Health Promotion (OHP) in Children: A Longitudinal Study involving NGO and Rural Community Groups in India In progress
Pamela Hardaker

F/T

Second De Montfort University 09/14-09/17 Detection of Movement State using a Computational Intelligence-Based Sensor Fusion System Towards the Real-Time Control of Existing Microprocessor- Controlled Prosthetic Leg Devices Commenced 10/14
Paris Connelly

F/T

Second De Montfort University 09/14-09/17 Exploring the Birth Experiences of Women with Female Genital Mutilation (FGM) and Midwives Commenced 10/14
Aamir Hussain

F/T

Second De Montfort University 09/14-09/17 Development and Testing of Novel Anti-Angiogenic Compounds Commenced 10/14
Getrude Chikura

F/T

Second De Montfort University 01/14-01/17 Development and Validation of a New Simple, Easy- to-use and Fit- for-Purpose Assessment Tool for the Clinical Diagnosis of Familial Breast Cancer In Progress

Georgina Benson

F/T

First De Montfort University 10/14-09/17 Development of Novel Nanosponge-Based Methods for the Detection and Quantification of Drugs in Biofluids and Surface Waters   Commenced 10/14

Isse Ali

F/T

Second De Montfort University 01/13/- 01/16 Clustering-Based Bioinformatics Approach for Analysis and Prediction of DNA  Methylation in Healthy and Diseased Tissues In progress near completion 

Benita Percival

F/T

First De Montfort University 10/15 - 09/18

Investigations of the Metabolism of First- and Second-Generation Statins using High-Resolution 19F and 1H NMR Analysis: Applications to Explore the Influence of Exercise Training Regimens

Commencing 10/15

Lucy Owen

F/T

Second De Montfort University 10/15 - 09/18

Development of Novel Synergistic Therapeutic Strategies to Combat Antimicrobial Resistance:

Critical Roles for Natural Products

Commencing 10/15

Kingsley Nwosu

F/T

First De Montfort University 10/15 - 09/18

Gaussian Process Models for Classification Purposes: Applications to the Analysis of Multidimensional Metabolomics and Chemometrics Datasets

Commencing 

10/15

Israa Anwer  Mohammedjumaah 

F/T

First De Montfort University 02/16 - 01/19

Metabolomics Investigations of Cardiovascular Disease Risk Factors (Tobacco Smoking, Diabetes and Obesity)

Commencing 02/16

                                                                                                                                                  

 

 

 

 

 

 

 

 

 

 

 

 

Externally funded research grants information

Grant Holder(s)

Funding Body

Period of Award

Amount

Title of Project

Grootveld, M. (with M. Miraftab).

University of Bolton

2010-2014

£60K

PhD Studentship: Design and Development of (1) The Next Generation of Prosthetic Veins and Arteries and (2) Biomarker Sensors for Application in Cardiovascular Diseases

Grootveld, M.  (with M.

Henriques, G. M. B. Soares )  

 

 

 

Fundaco para a Ciencia e a Tecnologia (FCT)

 

2009-2013

€75K 

Development of a New Anti-Microbial Fabric for Wound Dressings

Grootveld, M.

HEIF_5 Award

2013

£14K

Design and Formulation of Novel, Dual-Compartment, Non-Erosive Tooth-Whitening Products which Generate Chlorine Dioxide In Situ

Grootveld, M. (with R Arroo and M Edgar):

HEIF_5 Award

2013-2014

£30K

Establishment and Development of a Novel, Commercially-Viable Analytical/Bioanalytical Service System at Leicester School of Pharmacy. 

Grootveld M. 

Science Without Borders Post-Doctoral Research Award (12 months)

2014 (pending)

£23K

Evaluation of the Abilities of Antioxidants and Desensitising Agents to Diminish Post-Bleaching Tooth Sensitivity.

Grootveld, M.

UK and EU Industry: Healthcare Corporations

2013-2015

£44K

A range of Metabolomic Investigations of the Therapeutic Actions of Oral Healthcare Products

Grootveld M. HEIF Proof of Principle Award 2013-2014 £22K Investigations of the Tooth-Whitening Activities of Novel Chlorine Dioxide-Generating Systems at Neutral or Near-Neutral pH Values: A Clinical Trial to Evaluate their Efficacies at the Cervical, Body and Incisal Tooth Sites  
Grootveld M. HEIF DMU Collaborative Award 2013-2014 £20K Development and Application of Novel Computational Intelligence Techniques (CITs) to the Multivariate Analysis of Metabolomics Datasets  
Grootveld M. (with D. Sillence, F. Platt and D. Elizondo)  SPARKS Children’s Medical Research Charity   2014-2015 £51K Identification of Novel Biomarker Patterns for the Metabolomics Classification of Niemann-Pick Type C1 Disease and its Response to Treatment
Grootveld M. (with M. Dyer and S. Wagner) Hope Against Cancer Charity 2014-2016 £35K Identification of Biomarkers for Improved Prognosis of Hodgkin’s Lymphoma: A Pilot Investigation 

Internally funded research project information

Grant Holder(s)

Funding Body

Period of Award

Amount

Title of Project

Grootveld, M. (with R. Prasad and A. Farooqui).

 

DMU RCIF Award

2012-2014

£30K

Spectroscopy-Linked Multivariate Chemometric Investigations of Chronic Obstructive Pulmonary Disease (COPD) in Leicester.

Grootveld, M. (with D. Sillence).

 

 

DMU FHLS SMALL PROJECTS SCHEME

2013

£5K

Metabolic Classification of Niemann-Pick Type C1 Disease.

Grootveld, M. (with D. Sillence)

 

DMU FEES-ONLY SCHOLARSHIP AWARD

2013-2016

£12.4K

Development of Novel Strategies for the Analysis of Multivariate 1H NMR Datasets

Grootveld, M.  (with K. Huddersman and E. Jaroszkiewicz)

CARTER-GUNN FELLOWSHIP AWARD

2013

£8K

1NMR and HPLC Investigations of the Gamma-Irradiation Sterilisation of Drugs

Grootveld M. (with S. Handsley and M. Larkin) DMU High-Flyers PhD Scholarship 2014-2017 £59.5K Exploring the Birth Experiences of Women with Female Genital Mutilation (FGM) and Midwives
Grootveld M (with M. Maafi) DMU Full-Bursary PhD Scholarship 2014-2017 £55K Development of Novel Nanosponge-Based Methods for the Detection and Quantification of Drugs in Biofluids and Surface Waters  
Elizondo D, Passow B, and Grootveld M. DMU High-Flyers PhD Scholarship 2014-2017 £59.5K Detection of Movement State using a Computational Intelligence-Based Sensor Fusion System Towards the Real-Time Control of Existing Microprocessor- Controlled Prosthetic Leg Devices
Fretwell L, Rupareila K, Arroo R and Grootveld M. DMU Fees-Only PhD Scholarship 2014-2017 £12.6K Development and Testing of Novel Anti-Angiogenic Compounds
Rushworth J, Morris M, Fretwell L, Grootveld M, Slater, A, Dunford L, Sillence D.

DMU RCIF2 Award

2014-2017 £77.6K

Cell Imaging and Analysis (CIA) Facility: IlluminatingSustainable,World-ClassCollaborations in

Cell-Based Research

Huddersman K, Grootveld M, Arroo, R. 

DMU RCIF2 Award

 
2014-2017  

£55.5K 

Applications of a Novel Benchtop ESR Facility for the Rapid, ‘On-Site’ Analysis of Free Radicals and Transition Metal Ions in Clinical, Environmental and Food Samples.  

Grootveld M, Jaroszkiewicz E, Edgar, M, Taylor J.

DMU Fees-Only PhD Scholarship

2015-2018 £13K Investigations of the Metabolism of First- and Second-Generation Statins using High-Resolution 19F and 1H NMR Analysis: Applications to Explore the Influence of Exercise Training Regimens
Laird K, Grootveld M, Arroo  R. DMU Fees-Only PhD Scholarship 2015-2018   Development of Novel Synergistic Therapeutic Strategies to Combat Antimicrobial Resistance:Critical Roles for Natural Products 

Professional esteem indicators

Editorship of Reputable Scientific and Clinical Journals:

Member of the Editorial Boards of Current Metabolomics; International Journal of Medical and Clinical ResearchBio- Analytical Technique; SOJ Pharmacy & Pharmaceutical Sciences; Guest Editor for Computational and Mathematical Methods in Medicine.

PhD students currently supervised by Professor Grootveld