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Dr Naomi Martin

Job: Senior Lecturer in Immunology & Programme Leader MSc Advanced Biomedical Science

Faculty: Health and Life Sciences

School/department: School of Allied Health Sciences

Address: Hawthorn Building, De Montfort University, Leicester, LE1 9BH, United Kingdom

T: +44 (0) 116 201 3949

E: naomi.martin@dmu.ac.uk

W: https://www.dmu.ac.uk/about-dmu/academic-staff/health-and-life-sciences/naomi-martin/naomi-martin.aspx

 

Personal profile

Dr Martin is a Senior Lecturer in Immunology and Programme Leader for MSc Advanced Biomedical Science, and an Honorary Senior Lecturer in the Department of Respiratory Sciences at the University of Leicester and a Visiting Fellow in Clinical Immunology at Loughborough University 

Dr Martin is an experienced molecular and cellular immunologist, and an expert in flow cytometry. She has worked in academia and industry, and has a professional teaching qualification.

Dr Martin gained her undergraduate degree in Anatomy and Cell Biology at the University of Sheffield. She worked as a researcher at the world-renowned Great Ormond Street Hospital before returning to the University of Sheffield to complete a PhD in Neonatal Immunology. Dr Martin then went on to research the responses of the immune system to disease and infection at the Universities of Sheffield, Leeds and Leicester. She was awarded a Wellcome Value in People Fellowship, and then taught in Higher and Further Education, gaining a PGCE. Dr Martin worked as a scientific researcher in industry before returning to academia. 

RESEARCH: 

My research focuses on the function of microparticles (extracellular vesicles) in disease processes such as cancer, cardiovascular disease and diabetes, and their role in the susceptibility of certain ethnic groups to these diseases. I investigate how these novel markers of immune function and inflammation are altered phenotypically and their effects on disease pathophysiology and cellular dysfunction. I also investigate the effects of polluting microplastics on disease pathophysiology.

 I currently lead projects investigating: 

  • The role of ethnic microparticles on pathophysiology in cancer, cardiovascular disease and COVID-19.
  • Microplastics: are they involved in disease processes and progression?
  • The effects of small microparticles on disease progression and thrombosis in pancreatic cancer.
  • Metabolomics and metastasis in pancreatic cancer.
  • Do microplastics induce angiogenesis and metastasis in cancer?
  • The effects of omega-3 fatty acid supplementation on markers of inflammation and survival in pancreatic cancer patients.
  • The role of ACE-2 microparticles in COVID-19 thrombosis.
  • Autocrine motility factor expression and metastasis in cancer.

I have research collaborations with the University of Leicester, Leicester General Hospital, Leicester Royal Infirmary, Cranfield University, Loughborough University, Kingston University and University of Kentucky, USA. 

I supervise PhD and MRes students, taught MSc project students and undergraduate final year project students at DMU and University of Leicester. I also host placement internship students working on projects in my lab. 

Research group affiliations

Biomedical and Environmental Health Group

Publications and outputs

Amon B Hackney, Wen Y Chung, John Isherwood, Ashley R Dennison, Naomi Martin Stearoyl-CoA Desaturase 1 inhibitor treatment reduces the viability of pancreatic cancer. J Pancreatology (2021) (2022) 4: 170-177 doi:10.1097/JP9.0000000000000082

 

ML Young, PJ Highton, DS March, DR Churchward, CE Grantham, HML Young, MPM Graham-Brown, S Estruel, N Martin, NJ Brunskill, AC Smith, JO Burton, NC Bishop Intradialytic cycling does not exacerbate microparticles or circulating markers of systemic inflammation in haemodialysis patients. EJAP(2021)

doi.org/10.1007/s00421-021-04846-7

 

Naomi Martin, Xiaodie Tu, Alicia J Egan, Cordula Stover Complement Activation on Endothelial Cell-derived Microparticles – Key Determinant for Cardiovascular Risk in Patients with Systemic Lupus Erythematosus? Medicina (2020) 56, 533; doi:10.3390/medicina56100533

 

Roisin C Thomas, Ramair Kheder, Hasanain Alaridhee, Naomi Martin, Cordula Stover Complement Properdin Regulates the Metabolo-inflammatory Response to a High Fat Diet. Medicina (2020) 56, 484; doi:10.3390/medicina56090484

 

Patrick J Highton, Fernanda Reistenbach-Goltz, Naomi Martin, David J Stensel, Alice E. Thackray, Nicolette C Bishop Microparticle Responses to Aerobic Exercise and Standardised Meal Consumption. Medicine & Science in Sport & Exercise (2019) 51(9):1935-1943

 

Highton PJ, White AE, Nixon DGD, Wilkinson TJ, Neale J, Martin N, Bishop NC, Smith AC Influence of acute moderate- to high-intensity aerobic exercise on markers of immune function and microparticles in renal transplant recipients. Am J Physiol Renal Physiol (2021) 318, F76-F85; doi: 10.1152/ajprenal.00332.2019

 

Highton, Patrick J, Stensel, David J, Goltz, Fernanda R, Martin, Naomi, Bishop, Nicolette C. Aerobic Exercise Reduces the Pro-thrombotic Potential of Circulating Microparticles in Healthy Individuals Medicine & Science in Sports & Exercise (2018) 50(5S):274

 

Naomi Martin, Maurice R Dungey, James O Burton, Hannah M L Young, Alice C Smith, Nicolette C. Bishop Acute intradialytic exercise does not affect the phenotype or pro-thrombotic nature of microparticles but alters their function. Phys Rev (2018) 6(19): e13825. doi: 10.14814/phy2.13825

 

N Martin, AB Hackney, J Isherwood, F Runau, A Arshad, WY Chung, AR Dennison Reduced pro-coagulant phenotype of microparticles in pancreatic cancer patients on omega-3-supplemented gemcitabine treatment. Clinical Nutrition (2018) 37(1): S13 https://doi.org/10.1016/j.clnu.2018.06.1114

 

Patrick J Highton, Naomi Martin, Alice C Smith, James O Burton, Nicolette C Bishop Microparticles and Exercise in Clinical Populations. Exercise Immunology Review (2018) (24): 46-58

 

Martin N, Isherwood J, Madden M, Narayanan V, Mustafa N, Bhangal C, Farah S, Jones SE, Runau F, Chung WY, Arshad A, Dennison AR The effect of fish-oil supplemented gemcitabine treatment on Leukotriene B4 levels in pancreatic cancer. Clinical Nutrition (2017) 36(1): S214

 

Emma Watson, Joao Viana, David Wimbury, Naomi Martin, Neil Greening, Jonathan Barratt, Alice Smith. 

Intramuscular Molecular Responses to Resistance Exercise in Advanced Chronic Kidney Disease. Frontiers in Physiology (2017); https://doi.org/10.3389/fphys.2017.00541

 

Smith JE and Rebuck N Toxoplasma gondii strain variation and pathogenicity. In Microbial Foodbourne Diseases: Mechanisms of Pathogenesis and Toxin Synthesis (2000) Part IV Chapter 13 pages 405-431 Eds. Cary JW, Linz JE and Bhatnagar D. Technomic Publishing Company

 

Rebuck N, Croucher LJ, Hollander AP Distribution of two alternatively spliced variants of the Type II collagen Npropeptide compared with the C-propeptide in bovine chondrocyte pellet cultures. J Cell Biochem (1999) 75(1): 13-21

 

Bedlow AJ, Davies EG, Moss ALH, Rebuck N, Finn A, Marsden RA Pyoderma gangrenosum in a child with a congenital deficiency of leukocyte adherence glycoproteins. British J Dermatology (1998) 139(6): 1064-1067

 

Galea J, Rebuck N, Finn A, Manche H, Moat N Expression of soluble endothelial adhesion molecule expression in clinical cardiopulmonary bypass. Perfusion (1998) 13(5): 314-321

 

Galea J, Rebuck N, Finn A, Moat N Soluble endothelial adhesion molecule expression in clinical cardiopulmonary bypass.  J Mol Cell Cardiology (1997) 29(5): A109

 

Finn A, Morgan BP, Rebuck N, Klein N, Rogers CA, Hibbs M, Elliott M, Shore DF, Evans TW, Strobel S, Moat N Effects of inhibition of complement activation using recombinant soluble CR1 on neutrophil CD11b/CD18 and L-selectin expression and release of IL-8 and elastase in simulated cardiopulmonary bypass. J Thorac Cardiovasc Surg (1996) 111(2): 451-459

 

Rebuck N and Finn A Neutrophil adhesion molecules in term and preterm infants: normal or enhanced leukocyte integrins but defective L-selectin expression and shedding. Clin Exp Immunol (1995) 101: 183-189

 

Rebuck N and Finn A Polymorphonuclear leukocyte expression of CD11a/CD18, CD11b/CD18 and L-selectin in normal individuals. FEMS Immunology and Medical Microbiology (1994) 8: 189-196

 

Williams HJ, Rebuck N, Finn A Changes in leukocyte counts and soluble ICAM-1 and E-selectin during cardiopulmonary bypass in children. Nature Paediatric Research (1994) 35(2): 270

 

Finn A, Morgan BP, Rebuck N, Rogers CA, Moat N Effects of inhibition of complement activation using recombinant soluble CR1 on release of IL-8 and neutrophil activation in a model of acute inflammation. J Cell Biochem (1994) 18B: 317

 

Finn A, Rebuck N Measurement of adhesion molecule expression on neutrophils and fixation. JIM (1994) 171: 267268

 

Finn A, Moat N, Rebuck N, Strobel S, Elliott M Systemic inflammation during cardiopulmonary bypass: changes in neutrophil adhesive properties. Perfusion (1994) 8: 37-46

 

Finn A, Rebuck N, Moat N, Naik S, Klein N, Levinsky R, Strobel S, Elliott M Cytokines and mechanisms of capillary leakage after cardiopulmonary bypass. J Thorac Cardiovasc Surg (1993) 106: 567

 

Finn A, Moat N, Rebuck N, Klein N, Strobel S, Elliott M Changes in neutrophil CD11b/CD18 and L-selectin expression and release of Interleukin-8 and elastase in paediatric cardiopulmonary bypass. Agents and Actions (1993) 38: C44-C46

 

Moat N, Rebuck N, Shore DF, Evans TW, Finn A Humoral and cellular activation in a simulated extracorporeal circuit. Ann Thorac Surg (1993) 56: 1509-1514

 

Finn A, Rebuck N, Moat N Neutrophil activation during cardiopulmonary bypass. J Cardiovasc Surg (1992) 104: 1746-1748

 

Cutts AJ, Rebuck N, Reynolds GP D-Aspartate binding as a measurement of glutamate neurones in human brain tissue – effects of leucotomy. Neuroscience Letters (1992) Supplement (42) S1 

Key research outputs

Amon B Hackney, Wen Y Chung, John Isherwood, Ashley R Dennison, Naomi Martin Stearoyl-CoA Desaturase 1 inhibitor treatment reduces the viability of pancreatic cancer. J Pancreatology (2021) (2022) 4: 170-177 doi:10.1097/JP9.0000000000000082

 

Naomi Martin, Xiaodie Tu, Alicia J Egan, Cordula Stover Complement Activation on Endothelial Cell-derived Microparticles – Key Determinant for Cardiovascular Risk in Patients with Systemic Lupus Erythematosus? Medicina (2020) 56, 533; doi:10.3390/medicina56100533

 

N Martin, AB Hackney, J Isherwood, F Runau, A Arshad, WY Chung, AR Dennison Reduced pro-coagulant phenotype of microparticles in pancreatic cancer patients on omega-3-supplemented gemcitabine treatment. Clinical Nutrition (2018) 37(1): S13 https://doi.org/10.1016/j.clnu.2018.06.1114

 

Naomi Martin, Maurice R Dungey, James O Burton, Hannah M L Young, Alice C Smith, Nicolette C. Bishop Acute intradialytic exercise does not affect the phenotype or pro-thrombotic nature of microparticles but alters their function. Phys Rev (2018) 6(19): e13825. doi: 10.14814/phy2.13825

Research interests/expertise

RESEARCH INTERESTS:

  • Function of microparticles in disease processes
  • Ethnic minority disease susceptibility
  • Role of polluting microplastics in disease processes
  • Inflammation
  • Thrombosis

EXPERTISE:

  • Flow cytometric analysis of cells and microparticles, multicolour analysis of cell surface ligands, oxidative species, intracellular ligands and chemokines
  • Fluorescence microscopy
  • Development and use of ELISAs
  • ELISpot and Gel MicroDrop secretion assay
  • Tissue culture, including culture of hybridoma cell lines and primary cells
  • Molecular cloning (transfection of competent bacteria, clone selection, ligation)
  • In vivo models of human disease
  • SDS-PAGE gel electrophoresis, Western blotting and PCR
  • Immunocytochemistry and immunohistochemistry
  • Work with class II pathogenic organisms
  • Antibody production and purification, conjugation of FITC and biotin to antibodies
  • High speed video imaging
  • Protein and antigen purification including affinity, adsorption, IEX and gel filtration chromatography
  • Bioplex multiplex antibody testing
  • Nanosight technology

Areas of teaching

Advanced Pathophysiology and Diagnostics (MSc)

Cancer Biology (MSc)

Inflammation and Immunobiology (BSc)

Clinical Immunology (BSc)

Cellular Pathology (BSc)

Qualifications

BSc Anatomy and Cell Biology, University of Sheffield

PhD in Immunology, University of Sheffield

Post Graduate Certificate in post-compulsory Education, University of Bedfordshire

Courses taught

Advanced Biomedical Science MSc

Biomedical Science BSc

Medical Science BMedSci

Honours and awards

Wellcome Value In People Fellowship award 2008

Research Supervisor Award 2019 (nominated)

Vice-Chancellor’s Distinguished Teaching Award 2018 (nominated)

Membership of external committees

Midlands Innovation Flow Cytometry Group - De Montfort University representative

Membership of professional associations and societies

British Society for Immunology

The Institute for Learning

International Society of Exercise and Immunology

Flow Cytometry UK

Review Editor for Molecular Innate Immunity of Frontiers in Immunology

Projects

  • The role of ACE2+ microparticles in COVID-19 thrombosis
  • Interactions of ethnic minority microparticles with naive endothelial cells in vitro 
  • Ethnic minority microparticles as transporters of SARS-CoV-2 and their role in the COVID cytokine storm
  • Are polluting microplastics involved in disease processes and progression?
  • Autocrine motility factor receptor gp78 expression and metastasis in advanced pancreatic cancer 
  • Do microplastics induce angiogenesis and metastasis in cancer? 
  • Autocrine motility factor expression and metastasis in advanced lung cancer 

Dr Martin is very happy to discuss any self-funded MRes or PhD studentship projects

Martin Microparticle Lab

Current research students

Amon Hackney (DMU PhD)

Henna Munir (University of Leicester MSc)

Sreelekshmi Bhaskaran Pillai (DMU MSc)

Shannon Donnelly (DMU MSc)

Oliver Mannix (DMU MSc)

Swetha Reddy (DMU MSc)

Externally funded research grants information

Wellcome Value in People Research Fellowship (£91K)

2008

The impact of lectin pathway-mediated ischaemia/reperfusion injury in Chagas’ disease-induced autoimmune myocarditis

Internally funded research project information

DMU PhD Scholarship funding (£63K)

2019

Microplastics: are they involved in diseases processes and progression?

Health and Life Sciences, DMU faculty funding (£1K)

2019

Differential expression of adhesion molecules on ethnic microparticles

REF contributions

Emma Watson, Joao Viana, David Wimbury, Naomi Martin, Neil Greening, Jonathan Barratt, Alice Smith. 

Intramuscular Molecular Responses to Resistance Exercise in Advanced Chronic Kidney Disease. Frontiers in Physiology (2017); https://doi.org/10.3389/fphys.2017.00541

Community Engagement

I am an active STEM Ambassador and Inspiring the Future Ambassador, and have taken part in speed-interviews, mock interviews, Raising Girls’ Aspirations & Attainment in STEM subjects, What’s my Line careers assembly, at primary and secondary schools.

I was a Soapbox Science participant in June 2019. This was the first time Soapbox Science had been held in Leicester and gives the public an opportunity to meet and interact with scientists to increase the visibility and accessibility of STEM women in science. Soapbox Science follows the format of London Hyde Park’s Speaker’s Corner and since it was established in 2011 it has grown to take place in 30 locations around the world, featuring more than 1000 scientists and has been commended by the Prime Minister. I presented my research on how circulating 'microbubbles' play a role in the initiation and progression of disease.  

I have supervised 12 Nuffield A-level students doing projects in my lab over the summer periods.

External Academic Activities

I am an external PhD examiner at the University of Leicester.

I have acted as external module assessor for Coventry University Health and Social Care.

NM 160405