Professor Mingzhong Li

Job: Professor of Crystal Engineering & Drug Delivery

Faculty: Health and Life Sciences

School/department: Leicester School of Pharmacy

Address: De Montfort University, The Gateway, Leicester, LE1 9BH.

T: +44 (0)116 257 7132

E: mli@dmu.ac.uk

W: http://www.dmu.ac.uk/pharmacy

 

Personal profile

Prof Li's research is focused on solving key challenges facing the pharmaceutical industry for improvements in production quality and reduction in manufacturing costs through utilising cutting edge analytical techniques to explore optimal formulations starting from a molecular level characterisation and up to bulk properties of active pharmaceutical ingredients (APIs) and excipients and application of real time process analysis techniques for process monitoring and control.

Prof Li's current research areas include using co-crystallisation approach to modification of APIs’ physical and chemical properties, development of online particle sizing techniques for control of crystallisation processes and development of online process models for control of fluidised bed granulation processes.

Research group affiliations

Pharmaceutical technologies group.

Research interests/expertise

  • Pharmaceutical co-crystallisation
  • Granulation processes modelling; control and
    optimisation
  • Pre-formation development: in vitro dissolution and stability tests,
    computer simulation of in vitro dissolution test
  • Crystallisation/Co-crystallisation
  • Particle sizing
  • In vitro dissolution tests
  • Process modelling, control and optimisation
  • Multiphase flow modelling and computation.

Areas of teaching

  • Formulation
  • Analytical techniques
  • Chemometrics
  • Process technology.

Qualifications

  • PhD
  • MSc
  • BSc.

Courses taught

  • Pharmaceutical and Cosmetic Science
  • MSc Pharmaceutical Quality by Design.

Membership of external committees

  • Committee member, British Association for Crystal Growth
  • Particle technology subject group in Institution of Chemical Engineers

Membership of professional associations and societies

  • British Association for Crystal Growth
  • Academy of Pharmaceutical Sciences of Great Britain

Forthcoming events

  • A member of Conference Committee of “The 47th British Association for Crystal Growth annual conference, 27-29 June 2016, University of Leeds, Leeds, UK
  • A member of Conference Committee of “The 46th British Association for Crystal Growth annual conference, 21-23 June 2015, Queen Mary, London UK
  • Chair on “Surface Dissolution Imaging Symposium”, De Montfort University, 12-13 June, 2012.

Conference attendance

  • The 47th British Association for Crystal Growth annual conference, 27-29 June 2016, University of Leeds, Leeds UK
  • The 46th British Association for Crystal Growth annual conference, 21-23 June 2015, Queen Mary, London UK

Consultancy work

  • Co-crystallisation
  • Pre-formulation/formulation
  • In vitro dissolution
  • Pharmaceutical process modelling and control
  • QbD.

Current research students

  • Miss Fatima Idris, 3rd-year PhD student, 1st supervisor
  • Miss Preya Kirubakaran, 3rd-year PhD student, 1st supervisor
  • Miss Manreet Kaur, 3rd-year PhD student, 1st supervisor
  • Miss Linzie Bolus, 2nd-year PhD student, 1st supervisor
  • Mr. Jay Makadia, 1st-year PhD student, 1st supervisor
  • Mr. Morteza Haghshenas, 1st-year PhD student, 1st supervisor
  • Mr. Chufan Liang, 1st-year PhD student, 1st supervisor
  • Mr. Mayowa Adeyemi, 1st-year PhD studnet, 1st supervisor

Externally funded research grants information

  • In-process particle sizing by refractive index measurement, EPSRC, 01/09/2008-31/08/2010, £196072, PI.
  • Network Travel Grant, EPSRC Directed Assembly Network, £600, 2013, PI
  • Building the International Leading Pharmaceutical Research Capacity for the Pharmaceutical Technologies Group at De Montfort University, Higher Education Innovation fund, £8000, 2013-2014, PI
  • European Pharmaceutical Cocrystal Collaboration Network for EU Grant Applications, Higher Education Innovation fund, £2900, 2015, PI
  • Equipment Capital, Higher Education Innovation fund, £72,878, 2016, PI.
  • Developing Patient Centric Oral Medicines for Neglected Tropical Disease, EPSRC, EP/R021198/1, £71,217, 1/4/2018-31/3/2019, Principal Investigator.
  • Development of Patentable Novel Antimalarial Medicines, Funded by HEIF (Higher Education Innovation fund), £14,924, 1/01/2018 -31/07/2018, Principal investigator.

Internally funded research project information

  • Pharmaceutical technologies group network, RIF, 1/01/2010-31/07/2010, £5000, PI.
  • Equipment Capital, HEIF4, 2010, £67,850, PI

Published patents

PCT/GB2009/002599, Determining the particle size distribution of a suspension, UK.

Former PhD students

  • Dr. Ning Qiao, PhD, 2014, 1st supervisor

PhD thesis: Investigation of Carbamazepine-Nicotinamide cocrystal solubility and dissolution by the UV imaging system

  • Dr. Huolong Liu, PhD, 2014, 1st supervisor

PhD thesis: Modeling and control of batch pulsed top-spray fluidized bed granulation

  • Dr. Shi Qiu, PhD, 2015, 1st supervisor

PhD thesis: Effect of polymers on Carbamazepine cocrystals phase transformation and release profiles

  • Dr. Minshan Guo, PhD, 2018, 1st supervisor

PhD thesis: Investigating the Dissolution and Permeation Properties of Flufenamica Acid Cocrystals

Former MSc project students

2019: Mr Atif Qayyun, Miss Emma Holden, Miss natasha Buchanan, Miss Priyanka Ahmed

2018: Mr Chufan Liang, Mr. Chuhong Cheng, Mr. Weilin Tan, Mr. Mohammed Patel

2017: Miss Yasmine Alyassin; Mr. Saeed Gugu; Mr. Abdulrahman Nuhu; Mr. Aaron Gill; Mr. Rahman Ahmed

2016: Miss Jialu Situ; Miss Manreet Kaur; Miss Preyanthiny Kirubakaran; Mr. Jay Makadia

2015: Miss Junmin Lai; Mr. Balraj Rai; Miss Samya Khaled

2014: Miss Minshan Guo; Mr. Dillan Pattni; Mr. Xuechao Hou; Mr. Simron Rai

2012: Miss Fatma Ali; Miss  Ayobami Temitope Ajibola; Mr. Junaid Razaq; Mr. Rukhsar Tariq

Group news

    • January 2020: Welcome Mr Mayowa Adeyemi to join the group for PhD study
    • December 2019: Congratulations to Preya for publishing a paper entitled "Understanding the effects of a polymer on the surface dissolution of pharmaceutical cocrystals using combined experimental and molecular dynamics simulation approaches" in Molecular Pharmaceutics, https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.9b00955
    • November 2019: Congratulations to Manreet to be awarded a travel bursary to attend the GCRF NTD network Workshop in Techniques and Technologies in Drug Discovery to be held in Mendoza, Argentina  1-4 November 2019. https://www.linkedin.com/feed/update/urn:li:activity:6597573123493638144/
    • July 2019: Congratulations go to our post graduate research student, Miss  Manreet Kaur, 3rd year PhD student from the Pharmaceutical Technologies Group, who has been awarded the poster competitions  at the 50th annual meeting of the British Association of Crystal Growth (BACG) in London. https://www.linkedin.com/feed/update/urn:li:activity:6556926232737398784/
    • Story of Dr. Minshan Guo: https://www.dmu.ac.uk/about-dmu/news/2019/may/minshan-lands-lectureship-at-one-of-chinas-leading-universities.aspx
    • April 2019: Welcome Mr Chufan Liang to join the group for PhD study.
    • March 2019: Congratulations go to Linzie to win 2nd Prize of Research Degree Students' Poster Competition
    • September 2018: Welcome Mr Morteza Haghshenas to join the group for PhD study.
    • August 2018: Congratulations to Minshan to pass her Viva with minor corrections.
    • August 2018: Congratulations to Minshan for publishing a paper entitled "Investigating Permeation Behaviour of Flufenamic Acid Cocrystals using A Dissolution and Permeation System" in Molecular Pharmaceutics: http://dx.doi.org/10.1021/acs.molpharmaceut.8b00670 
    • July 2018: Welcome Mr Jay Makadia to join the group for PhD study.
    • April 2018: Congratulation to Linzie for winning Research Degree Students' Poster Competition 3rd Prize.
    • March 2018: Congratulation to the group to be awarded an EPSRC project.
    • January 2018: Welcome Dr. Ke Wang to join the group as a Research Assistant.
    • November 2017: Dr. Li is Guest Editor for Special Issue "Pharmaceutical Crystallisation Science and Engineering" in Pharmaceutics.
    • October 2017: Congratulations to Minshan for publishing a paper entitled "Insight into Flufenamic Acid Cocrystal Dissolution in the Presence of a Polymer in Solution: from Single Crystal to Powder Dissolution" in Molecular Pharmaceutics: http://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.7b00712.
    • July 2017: Congratulations go to our post graduate research student, Miss  Preya Kirubakaran,1st year PhD student from the Pharmaceutical Technologies Group, who has been awarded the 1st place of the poster competitions  at the 48th annual meeting of the British Association of Crystal Growth (BACG) in Manchester, from 27th to 30th of June, with more 150 delegates from 14 countries
    • February 2017: Congratulations on Linzie Bolus's success on the award of a high flyer scholarship. 
    • June 2016: Congratulations go to Dr. Shi Qiu, who has been awarded "Doctoral Thesis Prize" for the Faculty of Health and Life Sciences in the Doctoral Thesis Prize competition. Her thesis entitled: Effects of Polymers on Carbamazepine cocrystals phase transformation and release profiles.
Ming

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