Job: VC2020 Lecturer in Medicinal Chemistry
Faculty: Health and Life Sciences
School/department: Leicester School of Pharmacy
Address: De Montfort University, The Gateway, Leicester, LE1 9BH
T: +44 116 257 7443
I am a medicinal chemist with expertise in chemical biology, antibacterial and cancer chemotherapy, and the study of natural products as templates for future drug design.
Emphasis is given to the rational design, synthesis and bioassay-guided evaluation of “small-molecule” anticancer/antibacterial compounds, which are designed to interact with an individual protein target or predetermined DNA sequence. I am also interested in natural products isolation and purification from plants.
I graduated in Pharmacy from the University of Palermo, Italy, and then gained a PhD in medicinal chemistry at the UCL School of Pharmacy, London, where I was also appointed a Maplethorpe Postdoctoral Fellow.
I am a General Pharmaceutical Council registered pharmacist and I have spent some years working in community pharmacies.
Chemistry for Health, Medicinal Chemistry and Chemical Biology
DNA sequence-selective C8-linked pyrrolobenzodiazepine(PBD)-heterocyclic polyamide conjugates show anti-tubercular specific activities J. Antibiot., 2016, 69(12), 843–849.
Synthesis, anti-mycobacterial activity and DNA sequence-selectivity of a library of biaryl-motifs containing polyamides Bioorg. Med. Chem., 2015, 23(13), 3705-3711.
An Extended Pyrrolobenzodiazepine-Polyamide Conjugate with Selectivity for a DNA Sequence Containing the ICB2 Transcription Factor Binding Site J. Med. Chem. 2013, 56(16), 6339-6351.
Research interests in anti-cancer and anti-tuberculosis drug discovery:
PHAR1603; PHAR3604; PHCO1302; PHCO3312
RSC, AACR, GPhC, FHEA
Current research activities:
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