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Dr Adam Moroz

Job: Senior Research Fellow

Faculty: Technology

School/department: School of Engineering and Sustainable Development

Research group(s): Advanced Manufacturing Processes and Mechatronics Centre (AMPMC)

Address: De Montfort University, The Gateway, Leicester, LE1 9BH UK

T: +44 (0)116 250 66 49

E: AMoroz@dmu.ac.uk

W: www.rpmg.dmu.ac.uk

 

Personal profile

More than 25 years of research experience in biophysics and biochemistry, working with spectroscopic experimental techniques and theoretical statistical and mathematical modelling in biochemistry, biophysics, physiology (normal and pathological – drug intoxication and cancer) and pharmacology, contributing to the non-linear absorption and resorption problems, applications of optimal control methods.  In particular, my biochemical research included studies in neuro-active amino acids, hormones, vitamins, liver pathology, biological stress, different intoxications, complex metabolic disorder.  From perspective of optimality and systems biology I am pursuing research in tissue regeneration, both in healthy and pathological conditions, and in molecular signalling mechanisms in tissue functioning.  I am also interested in theory of dynamical systems, maximum energy dissipation principle in biophysics, bioenergetics, bio-kinetics, biochemistry, biology; data analysis/mining and statistical modelling, stochastic processes and probability, molecular signal analysis, cooperative transitions in biological systems.

Research group affiliations

Additive Manufacturing Technology Group within Advanced Manufacturing Processes and Mechatronics Centre (AMPMC)

Integration of Engineering Technologies and Techniques in Biomedicine

Department of Engineering, Faculty of Technology, De Montfort University, Leicester

Publications and outputs 

 Click here for a full listing of Adam Moroz's publications and outputs.

Key research outputs

Moroz A., The common extremalities in biology and physics, pp.379. Second Edition. Elsevier Insights, 2012.

Moroz A., Wimpenny D.I., (2011) On the variational framework employing optimal control for biochemical thermodynamics. Chemical Physics, 380, 77-85. Doi:10.1016/j.chemphys.2010.12.009.

Moroz A. (2010). Cooperative and collective effects in light of the maximum energy dissipation principle, Physics Letters A, 374, 2005-2010.

Moroz A, (2009). A variational framework for nonlinear chemical thermodynamics employing the maximum energy dissipation principle, J Phys Chem B, 113, 8086-8090.

Moroz A, (2008). On a variational formulation of the Maximum Energy Dissipation principle for nonequilibrium chemical thermodynamics. Chem Phys Lett, 427, 448-452.

Research interests/expertise

- bioengineering– additive manufacturing technology in combination with optimisation techniques in development of new generation of bone implants/ scaffolds.

- biophysics and biochemistry  - molecular mechanisms (particularly based on Schiff Base) of post-translational modification of enzymes, receptor and messengers at drug intoxication.  Mechanisms and processes involved in bone remodelling.  Maximum energy dissipation approach to biokinetics and bio-evolution.

- biokinetical modelling (binding-, enzyme-, pharmaco-kinetics).

- multileveled physiological modelling with a number of compartments from 10 to 20 including enzyme metabolism of substrates and non linear absorption and resorption mechanisms.

- bio-medical statistical modelling: factor-, cluster-, survival-, discriminant- and regression-analysis; Matlab, MathCad, SAS, C++.

- dynamical optimal control in applications to physiological kinetics, cancer, pharmaco-kinetics and treatment optimisation, binding, enzyme and cellular models.

- hierarchical systems control approachto mathematical modelling of the different tissues (particularly bone tissue) and organs.

- bioenergetics – optimisational principles in biokinetics, maximum energy dissipation principle in biophysics, biochemistry, system biology, cooperativity.

-   cell biology  -  role of osteoclasts, osteoblasts, osteocytes in the bone tissue turnover. 

Areas of teaching

- Rapid Product Development MSc Course Leader;

Module leader for the following subjects:

- Rapid Prototyping Techniques
- Research Methods
- Virtual Prototyping

Qualifications

Cand.Sci., PhD

Courses taught

Biophysics

Biochemistry

Mathematical Modelling

Membership of professional associations and societies

European Society for Mathematical and Theoretical Biology

Conference attendance

European Conference on Mathematical and Theoretical Biology (ECMTB 2011) Krakow, Poland, June 28- July 2, 2011.

The 2nd International Conference on Polymers & Moulds Innovations(PMI 2007), Ghent, Belgium, 2007.

European Conference on Mathematical and Theoretical Biology (ECMTB 2005) Dresden, Germany, July 18-22, 2005.

Current research students

Rafat Madani, PhD, 1st supervisor.

Khalid Alrbaey, PhD, 2nd supervisor.

Li Ju Wei, PhD, 2nd supervisor.

Professional esteem indicators

Editorial board member of Journal of Clinical Rehabilitative Tissue Engineering Research 2005-2010.

Reviewer for International Journal “Biomechanics and Modelling in Mechanobiology”, Springer.

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