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Dr Sangeeta Tanna

Job: Reader in Pharmaceutical Bioanalysis

Faculty: Health and Life Sciences

School/department: Leicester School of Pharmacy

Address: De Montfort, University, The Gateway, Leicester, LE1 9BH.

T: +44 (0)116 207 8274

E: stanna@dmu.ac.uk

W: www.dmu.ac.uk/research/research-faculties-and-institutes/health-and-life-sciences/dried-blood-spot-analysis/dried-blood-spot-analysis.aspx

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Personal profile

Dr Sangeeta Tanna's main interests and expertise are in the following areas:

  • Dried blood spot (DBS) analysis
  • Quantitative bioanalysis
  • LC-HRMS
  • LC-MS/MS
  • Medicine adherence
  • Therapeutic drug monitoring
  • Clinical pharmacy practice
  • Paediatric pharmacokinetics
  • Paediatric biomarkers
  • Counterfeit drugs/medicines
  • Food safety.

She is particularly interested in the application of analytical techniques to the determination of low levels of target analytes, principally involving improvements to healthcare of patients. There include:

  • Dried blood spot (DBS) analysis for paediatric pharmacokinetic studies and patient care
  • Assessment of adherence to cardiovascular medications using DBS analysis
  • Investigation, detection and analysis of counterfeit medicines
  • Development of in vitro characterisation and analytical methods for a novel glucose-responsive, self-regulated insulin delivery system.

Research group affiliations

Pharmacy Practice Research Group

Publications and outputs 

Click here for a full listing of Sangeeta Tanna's publications and outputs|.

Areas of teaching

  • Pharmaceutics
  • Biopharmaceutics
  • Novel drug delivery systems
  • Paediatric formulations and drug delivery
  • Extemporaneous dispensing
  • Bioanalysis.

Courses taught

  • MPharm Pharmacy
  • BSc Pharmaceutical and Cosmetic Science
  • MSc Pharmaceutical Quality by Design
  • Postgraduate workshop training session on “How to design effective posters”.

Honours and awards

Nominated for Times Higher Education (THE) Research Project of the Year 2012
Blood Spot Analysis.
Tanna S and Lawson G
November 2012

Royal Society of Chemistry – Analytical Methods Prize 2010
Analysis of dried blood spots – the potential for paediatric pharmacokinetic studies of captopril.
Tanna S, Pandya H, Mulla H, Titman C, and Lawson G.
RSC Analytical Research Forum. Loughborough University. 26-28 July 2010

British Pharmaceutical Conference 2009 – Science Poster Prize
The use of blood spot analysis in paediatric care - From laboratory to bedside and back again.
Lawson G, Pandya H, Mulla H and Tanna S
Science @ BPC2009 Royal Pharmaceutical Society. Manchester Central. Sept 7-9 2009.

Membership of professional associations and societies

  • British Mass Spectrometry Society 2011-present
  • Royal Society of Chemistry 2010 - Ordinary Member.
  • Pharmaceutical Sciences Group 1996-present.

Conference attendance

Invited Lectures

Tanna S and Lawson G. (2013) Cardiovascular drug medication compliance assessed by dried blood spot sampling techniques. Invited lecture at the 4th International Conference and Exhibition on Analytical Techniques. Las Vegas, USA 15-17 October 2013 Journal of Analytical and Bioanalytical Techniques, 4 (5): 51

Lawson G, Armitage R, Alhedethe A and Tanna S. (2013) Rapid identification of counterfeit pills by ATR FT/IR analysis of crushed samples. Invited lecture at the 4th International Conference and Exhibition on Analytical Techniques. Las Vegas, USA 15-17 October 2013 Journal of Analytical and Bioanalytical Techniques, 4 (5): 50

Tanna S and Lawson G. (2013) Blood Spot Analysis – Paediatrics to Pensioners. Invited public lecture at the Festival of Ideas, De Montfort University, Leicester UK, 23 April 2013

Lawson G, Armitage R and Tanna S. (2012) Identification of Counterfeit Drugs. Invited public lecture at the Cafe Scientifique event, Nanjing, China, November 2012

Tanna S and Lawson G. (2012) Dried Blood Spot (DBS) Analysis for Healthcare Applications. Invited public lecture at the Cafe Scientific event, Nanjing, China, November 2012

Lawson G, Armitage R and Tanna S. (2012) Identification of counterfeit medicines. Invited Lecture. 7th Annual Pharmaceutical Anti-Counterfeiting Meeting. 2012, Visiongain Conference Centre, Barbican, London, UK. 26-27 June 2012.

Lawson G, Armitage R and Tanna S (2012) Identification of counterfeit medicines. Invited Lecture. Conference on International Biology and Medicine Innovative Industrialization (IBMII). Chongqing Convention Centre, Chongqing, China, April 2012.

Tanna S. and Lawson G. (2012) Dried blood spot (DBS) analysis for healthcare applications. Invited Lecture. Conference of International Biology and Medicine Innovative Industrialization (IBMII). Chongqing Convention Centre, Chongqing, China, April 2012

Lawson G, Ross G, Sage A, Mulla H, Pandya H and Tanna S. (2010) Potential of the QToF in Paediatric Biomarking. Invited Lecture. 1st International Pediatric Biomarker Symposium. Congress Park, Igls Austria. 4-6 Feb 2010

Invited Poster Presentations

Tanna S, Patel P, Mulla H and Lawson G. (2010) Dried blood spot analysis – a comparison of SIM, MSMS and accurate mass TOF analyses for selected drugs. 27th LC-MS Montreux Symposium, Montreux, Switzerland, 10-12 November 2010

Tanna S, Pandya H, Mulla H, Titman C, and Lawson G. (2010) Analysis of dried blood spots – the potential for paediatric pharmacokinetic studies of captopril. RSC Analytical Research Forum. Loughborough University. 26-28 July 2010

Lawson G, Mulla H, Ross G, Sage A and Tanna S. (2010) Accurate mass versus tandem mass measurement of paediatric biomarkers. RSC Analytical Research Forum. Loughborough University. 26-28 July 2010

Tanna S, Pandya H, Mulla H, Titman C, and Lawson G. (2010) Analysis of dried blood spots – the potential for paediatric pharmacokinetic studies of captopril. 1st

International Pediatric Biomarker Symposium. Congresspark. Igls, Austria. 4-6 Feb 2010.

Poster Presentations

Tanna S, Armitage R, Lawson G. (2013) Identification of counterfeit pills - Is rapid instrumental analysis possible? Proceedings of The 24th International Symposium on Pharmaceutical and Biomedical Analysis. Bologna, Italy. 30 June-3 July 2013

Lawson G, Cocks E. and Tanna S. (2013) Liquid chromatography-high resolution mass spectrometry applied to therapeutic drug monitoring using DBS sampling. Proceedings of The 24th International Symposium on Pharmaceutical and Biomedical Analysis. Bologna, Italy. 30 June-3 July 2013.

Tanna S, Cocks E. and Lawson G. (2013) Is the patient taking their 'heart' pills? A dried blood spot sample - LC-HRMS assay. Proceedings of The 24th International Symposium on Pharmaceutical and Biomedical Analysis. Bologna, Italy. 30 June-3 July 2013

Tanna S, Patel P, Mulla H. and Lawson G. (2011) Dried blood spot analysis to improve paediatric medication. Separation Science Asia. Singapore. 27-28 July 2011

Lawson G, Cocks E. and Tanna S. (2011) High resolution mass spectrometry for quantitative analysis of dried blood spots. Separation Science Asia. Singapore, 27-28 July 2011

Patel P, Pandya H, Spooner N, Della Pasque O, Gade S, Kairamknoda V, Lawson G, Tanna S, Mulla H. (2011) Dried blood spots and sparse sampling: A perfect combination for minimally invasive PK/PD studies in children. Population Approach Group Europe (PAGE) Meeting, Athens, Greece, June 2011

Tanna S, Cocks E and Lawson G. (2011) High resolution mass spectrometry for analysis of selected drugs in dried blood spots. 59th Conference on Mass Spectrometry and Allied Topics ASMS Meeting, Denver, Colorado, USA 5 – 9 June 2011

Lawson G, Mulla H, Patel P and Tanna S. (2011) Examples of dried blood spot sampling and analysis to improve paediatric medicine. 59th Conference on Mass Spectrometry and Allied Topics. ASMS Meeting, Denver, Colorado, USA 5-9 June 2011

Patel P, Lawson G, Tanna S, Mulla H. (2009) Facilitating paediatric PK studies: utility of the dried blood spot. Pharmacokinetics UK Conference, Birmingham UK, November 2009

Patel P, Lawson G, Mulla H and Tanna S. (2009) Applying dried blood spot analysis: the pathway to better paediatric care. Science @ BPC2009 Royal Pharmaceutical Society. Manchester Central, UK September 7-9 2009.

Lawson G, Pandya H, Mulla H and Tanna S. (2009) The use of blood spot analysis in paediatric care - From laboratory to bedside and back again. Science @ BPC2009 Royal Pharmaceutical Society. Manchester Central, UK. September 7-9 2009.

Lawson G, Coffey J, Titman C and Tanna S. (2009) Dried blood spot analyses by Ion Trap – Time of Flight Mass Spectrometry, the potential for improved child care? 18th Intl Mass Spectrometry Conference, PWA 427, Bremen, Germany Aug 30 – Sept 4 2009

Lawson G, Patel, P and Tanna S. The use of dried blood spot analysis in paediatric care – how mass spectrometry can direct child medication. 18th Intl Mass Spectrometry Conference, PMM 468, Bremen, Germany Aug 30 – Sept 4 2009

Tanna S, Lawson G Mulla H and Pandya H From laboratory to bedside and back again – The use of blood spot analysis in paediatric care. ACCP/ESCP International Congress on Clinical Pharmacy. Orange County Convention Centre, Orlando, Fl. USA. April 24 -28th.2009.

Current research students

4 PhD students

Externally funded research grants information

Dried blood spot analysis. April 2012. British Council support on UK-Chongqing Collaboration on Technology Transfer and Research Role PI.

Assessment of compliance for cardiovascular medications using dried blood spot analysis. 2011 – 2012. The Gunn and Carter Fellowship
Role PI. Collaborators UHL and University of Leicester. Contract  £18,000.

Pharmacokinetic investigation of caffeine in neonatal children during clinical care. 2008-2011.  Joint funding from GlaxoSmithKline/ UHL NHS Trust/DMU.  Role CI. Collaborators GSK, UHL and University of Leicester.  Contract value £75,000.

Development of a model for monitoring therapeutic levels of dexamethasone in neonates via microanalysis. 2008 – 2011 UHL NHS Trust consumables funding .  Role CI. Contract value £21,000.

Assessing the Bioequivalence of Unlicensed Liquid Captopril formulations used in the treatment of Children with Heart Failure. 2008-2010.  NIHR Research for Patient Benefit Funding.  Joint research with UHL NHS Trust.   Role CI. Contract value £51,774.

Novel methods for paediatric drug monitoring using microanalysis. 2007 – 2008 NIHR NEAT (now i4i) Funding Role PI.  Contract £68,296

Internally funded research project information

Tandem Mass Spectrometry Project. Contract value £30,000. Role CI (with Dr G Lawson PI) DMU HEIF Funded £30,000.

Tandem Mass spectrometry analyses of dried blood spots. 2010-13 Contract value £300,000. Role CI (with Dr G Lawson PI) DMU RIF funded.

Development of a model for monitoring therapeutic levels of dexamethasone in neonates via microanalysis. DMU PhD Student Bursary CI and 2nd supervisor. Collaborators UHL NHS Trust, Sheffield Children’s Hospital, GSK plc. 2008-2011. Contract value £40,500.

Case studies

1.The blood spot analysis research and its potential impact on improving healthcare received extensive media coverage during a British Council sponsored visit to Chongqing, China in April 2012. It was widely covered by 20 national and local media, including CCTV, Chongqing TV, Xinhua News Agency, Guang Ming Daily People’s Daily, HongKong Wenhui Po, people.com.cn, CQ.QQ.com etc. The link below is Chongqing TV’s coverage of the event at its satellite news programme.
http://v.youku.com/v_show/id_XMzg3Nzg2OTk2.html|

2. In September 2011 the pioneering use of dried blood spot methods to monitor prescription compliance among patients taking cardiovascular medications was the subject of local and national media coverage. This included television coverage on BBC national and local news in addition to a live BBC Radio Leicester interview. It was featured on the BBC news website at: http://www.bbc.co.uk/news/uk-england-leicestershire-15002237|

3. The following was published in the Leicester Mercury of Saturday, August 21, 2010:
http://www.thisisleicestershire.co.uk/news/Baby-test-team-win-award/article-2552713-detail/article.html|

Baby test team win top award

A test pioneered by De Montfort University| experts, which could help improve care and treatment of sick newborn babies, has won a top award.

The Royal Society of Chemistry Analytical Methods Prize 2010 was awarded to Dr Sangeeta Tanna and Dr Graham Lawson for their work.

The test measures how much of a drug is in a baby's blood from a single drop and will allow medics to treat them more effectively.

It could help revolutionise how drugs are used to treat critically-ill newborn babies.

Sangeeta Tanner

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