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Dr Michael Randles

Job: Early Career Academic Fellow

School/department: School of Allied Health Sciences

Address: De Montfort University, The Gateway, Leicester, LE1 9BH

T: +44 (0)116 257 7963

E: Michael.randles@dmu.ac.uk

W: https://www.researchgate.net/profile/Michael_Randles

 

Publications and outputs 

M. J. Randles, S. Collinson, T. Starborg, A. Mironov, M. Krendel, T. Wlodkowski, F. Schaffer, E. Koenigshausen, L. Sellin, I. Roberts, K. E. Kadler, J. H. Miner and R. Lennon."Three-dimensional electron microscopy reveals the evolution of glomerular barrier injury." Scientific Reports (2016).

M. J. Randles, M. J. Humphriesand R. Lennon "Proteomic definitions of basement membrane composition in health and disease." Matrix biol.(2016)

M. J. Randles, A.S.Woolf, J.L. Huang, A Byron, J.D. Humphries, K.L. Price, M Kolatsi-Joannou, S. Collinson, T. Denny, D. Knight, A. Mironov, T. Starborg, R. Korstanje, M.J. Humphries, D.A. Long, R. Lennon "Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization."       J Am Soc Nephrol,** (2015).

M. J. Randles+, A. Byron+, J. D. Humphries, A. Mironov, H. Hamidi, S. Harris, P. W. Mathieson, M. A. Saleem, S. S. Satchell, R. Zent, M. J. Humphries and R. Lennon. "Glomerular Cell Cross-Talk Influences Composition and Assembly of Extracellular Matrix." J Am Soc Nephrol,**  (2014).

R. Coletta, N. A. Roberts, M. J. Randles, A. Morabito and A. S. Woolf. "Exogenous transforming growth factor -β 1 enhances smooth muscle differentiation in embryonic mouse jejunal explants" Journal of Tissue Engineering and Regenerative Medicine, (2016).

R. Lennon, H. M. Stuart, A. Bierzynska, M. J. Randles, B. Kerr, K. A. Hillman, G. Batra, J. Campbell, H. Storey, F. A. Flinter, A. Koziell, G. I. Welsh, M. A. Saleem, N. J. Webb, A. S. Woolf. Coinheritance of COL4A5 and MYO1E mutations accentuate the severity of kidney disease.  Pediatr Nephrol, (2015).

R. Lennon, A. Byron, J. D. Humphries, M. J. Randles, A. Carisey, S. Murphy, D. Knight, P. E. Brenchley, R. Zent and M. J. Humphries. "Global Analysis Reveals the Complexity of the Human Glomerular Extracellular Matrix." J Am Soc Nephrol,  (2014).

R. Lennon, M. J. Randles and M. J. Humphries ''The importance of podocyte adhesion for a healthy glomerulus'' Frontiers in endocrinology, (2014).

R. Lennon, M. J. Randles "Applying proteomics to investigate basement membranes in health and disease" Basement membranes the book, (2015).

M. J. Randles "The kidney filtration barrier" Biological sciences review, volume 28.3 (2016).

Key research outputs

M. J. Randles, S. Collinson, T. Starborg, A. Mironov, M. Krendel, T. Wlodkowski, F. Schaffer, E. Koenigshausen, L. Sellin, I. Roberts, K. E. Kadler, J. H. Miner and R. Lennon."Three-dimensional electron microscopy reveals the evolution of glomerular barrier injury." Scientific Reports (2016).

M. J. Randles, M. J. Humphriesand R. Lennon "Proteomic definitions of basement membrane composition in health and disease." Matrix biol.(2016)

M. J. Randles, A.S.Woolf, J.L. Huang, A Byron, J.D. Humphries, K.L. Price, M Kolatsi-Joannou, S. Collinson, T. Denny, D. Knight, A. Mironov, T. Starborg, R. Korstanje, M.J. Humphries, D.A. Long, R. Lennon "Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization."       J Am Soc Nephrol,** (2015).

M. J. Randles+, A. Byron+, J. D. Humphries, A. Mironov, H. Hamidi, S. Harris, P. W. Mathieson, M. A. Saleem, S. S. Satchell, R. Zent, M. J. Humphries and R. Lennon. "Glomerular Cell Cross-Talk Influences Composition and Assembly of Extracellular Matrix." J Am Soc Nephrol,**  (2014).

R. Lennon, M. J. Randles and M. J. Humphries ''The importance of podocyte adhesion for a healthy glomerulus'' Frontiers in endocrinology, (2014).

Areas of teaching

  • Proteomics
  • Cell Biology
  • Physiology
  • Genetics
  • Structure and function of cells and tissues

Qualifications

  • BSc Hons Medical Biochemistry, The University of Bristol
  • PhD Medicine, The University of Manchester

Courses taught

  • Biomedical sciences

Honours and awards

2016 Oral presentation prize winner American society for matrix biology. 
St. Petersburg Florida USA. 

2016 Poster prize winner UK kidney week. 
Birmingham, UK. 

2015 Poster prize winner Alport workshop. 
Göttingen, Germany. 

2014 Poster prize winner British society for matrix biology. 
Bristol, UK. 

2013 Best oral presentation The Gordon Research Seminar for Collagen in the Context of Regenerative Medicine.
New London, New Hampshire, USA. 

Conference attendance

2017    Alport UK patient information day, invited speaker, London UK.

2016    American society for matrix biology St. Petersburg Florida USA (oral).

2016    Renal association UK Kidney Week poster prize winner, Birmingham UK.

2015    American Society of Nephrology Kidney Week San Diego, California, USA
            (poster).

2015    Alport workshop Göttingen, Germany (poster presentation).

2015    Faculty of Medical and Human Sciences Showcase, The University of                             Manchester UK (oral).

2014    Nephrogenesis workshop Manchester, UK (oral).         

2014    British society for matrix biology, Bristol, UK (poster).

2014    10th International podocyte meeting Freiburg, Germany (oral).

2014    MINT seminar series Manchester Royal Infirmary, Manchester UK (oral).

2013    The Gordon Research Conference for  Collagen in the Context of
            Regenerative Medicine New London, New Hampshire, USA (oral).

2013    British Transplant Society & Renal Association Meeting Bournemouth, UK                       (poster).

2012    Nephrogenesis workshop Liverpool, UK (poster).

2012    The joint European Bioinformatics Institute and Wellcome Trust advanced                       course: Proteomics Bioinfomatics Hinxton, Cambridge, UK (poster).

Externally funded research grants information

Kidneys for Life research grant £6,500

https://kidneysforlife.org/our-research/research-projects/investigating-integrin-activation-in-nephrotic-syndrome/ 

Michael Randles 800

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