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Dr Graham Lawson

Job: PL Forensic Analysis

Faculty: Health and Life Sciences

School/department: Leicester School of Pharmacy

Address: De Montfort University, The Gateway, Leicester, LE1 9BH.

T: +44 (0)116 257 7129

E: glawson@dmu.ac.uk

W: www.dmu.ac.uk/hls

 

Personal profile

  • Low level chemical threat detection
  • Analysis of composition of historical artwork
  • Dried blood spot (DBS) analysis
  • Quantitative bioanalysis
  • LC-HRMS
  • LC-MS/MS
  • Medicine adherence
  • Therapeutic drug monitoring
  • Counterfeit drugs/medicines
  • Food safety.

Publications and outputs 

Click here for a full listing of Graham Lawson's publications and outputs|.

Research interests/expertise

  • Application of instrumental techniques to low level detection principally concerning threats to health, eg patients, workers or the general public
  • Neonatal patient care based on dry blood spot analysis
  • Investigation / detection of counterfeit pharmaceutical products
  • Security applications of selected detection systems
  • Safety of plastic packaging in food and pharmaceutical applications
  • Forensic investigations of historical paintings particularly post Byzantine icons
  • Work extended to include applications to the history and conservation of works of art
  • Dried blood spot (analysis)
  • LC-HRMS
  • Therapeutic drug monitoring
  • Food additive exposure assessment
  • Medicine adherence assessment
  • Contaminant migration into food
  • Paediatric biomarkers
  • Paediatric pharmacokinetics
  • Counterfeit products medicines, drugs and food.

Areas of teaching

  • Instrumental Analytical Forensic Science
  • Gas chromatography mass spectrometry
  • chromatography mass spectrometry
  • LC-MS/MS
  • SPE applied to the above areas
  • Identification of counterfeit products: medicines, foods and other consumer items.

Qualifications

BSc (Hons) PhD

Courses taught

BSc Forensic Science

Honours and awards

Nominated for Times Higher Education (THE) Research Project of the Year 2012
Blood Spot Analysis.
Tanna S and Lawson G
November 2012

Royal Society of Chemistry – Analytical Methods Prize 2010
Analysis of dried blood spots – the potential for paediatric pharmacokinetic studies of captopril.
Tanna S, Pandya H, Mulla H, Titman C, and Lawson G.
RSC Analytical Research Forum. Loughborough University. 26-28 July 2010

British Pharmaceutical Conference 2009 – Science Poster Prize
The use of blood spot analysis in paediatric care - From laboratory to bedside and back again.
Lawson G, Pandya H, Mulla H and Tanna S
Science @ BPC2009 Royal Pharmaceutical Society. Manchester Central. Sept 7-9 2009.

Membership of professional associations and societies

Royal Society of Chemistry. 2010 - Ordinary Member.

Conference attendance

Invited Lectures

Tanna S and Lawson G. (2013) Cardiovascular drug medication compliance assessed by dried blood spot sampling techniques. Invited lecture at the 4th International Conference and Exhibition on Analytical Techniques. Las Vegas, USA 15-17 October 2013 Journal of Analytical and Bioanalytical Techniques, 4 (5): 51

Lawson G, Armitage R, Alhedethe A and Tanna S. (2013) Rapid identification of counterfeit pills by ATR FT/IR analysis of crushed samples. Invited lecture at the 4th International Conference and Exhibition on Analytical Techniques. Las Vegas, USA 15-17 October 2013 Journal of Analytical and Bioanalytical Techniques, 4 (5): 50

Tanna S and Lawson G. (2013) Blood Spot Analysis – Paediatrics to Pensioners. Invited public lecture at the Festival of Ideas, De Montfort University, Leicester UK, 23 April 2013

Lawson G, Armitage R and Tanna S. (2012) Identification of Counterfeit Drugs. Invited public lecture at the Cafe Scientifique event, Nanjing, China, November 2012

Tanna S and Lawson G. (2012) Dried Blood Spot (DBS) Analysis for Healthcare Applications. Invited public lecture at the Cafe Scientific event, Nanjing, China, November 2012

Lawson G, Armitage R and Tanna S. (2012) Identification of counterfeit medicines. Invited Lecture. 7th Annual Pharmaceutical Anti-Counterfeiting Meeting. 2012, Visiongain Conference Centre, Barbican, London, UK. 26-27 June 2012.

Lawson G, Armitage R and Tanna S (2012) Identification of counterfeit medicines. Invited Lecture. Conference on International Biology and Medicine Innovative Industrialization (IBMII). Chongqing Convention Centre, Chongqing, China, April 2012.

Tanna S. and Lawson G. (2012) Dried blood spot (DBS) analysis for healthcare applications. Invited Lecture. Conference of International Biology and Medicine Innovative Industrialization (IBMII). Chongqing Convention Centre, Chongqing, China, April 2012

Lawson G, Ross G, Sage A, Mulla H, Pandya H and Tanna S. (2010) Potential of the QToF in Paediatric Biomarking. Invited Lecture. 1st International Pediatric Biomarker Symposium. Congress Park, Igls Austria. 4-6 Feb 2010

Invited Poster Presentations

Tanna S, Patel P, Mulla H and Lawson G. (2010) Dried blood spot analysis – a comparison of SIM, MSMS and accurate mass TOF analyses for selected drugs. 27th LC-MS Montreux Symposium, Montreux, Switzerland, 10-12 November 2010

Tanna S, Pandya H, Mulla H, Titman C, and Lawson G. (2010) Analysis of dried blood spots – the potential for paediatric pharmacokinetic studies of captopril. RSC Analytical Research Forum. Loughborough University. 26-28 July 2010

Lawson G, Mulla H, Ross G, Sage A and Tanna S. (2010) Accurate mass versus tandem mass measurement of paediatric biomarkers. RSC Analytical Research Forum. Loughborough University. 26-28 July 2010

Tanna S, Pandya H, Mulla H, Titman C, and Lawson G. (2010) Analysis of dried blood spots – the potential for paediatric pharmacokinetic studies of captopril. 1st

International Pediatric Biomarker Symposium. Congresspark. Igls, Austria. 4-6 Feb 2010.

Poster Presentations

Tanna S, Armitage R, Lawson G. (2013) Identification of counterfeit pills - Is rapid instrumental analysis possible? Proceedings of The 24th International Symposium on Pharmaceutical and Biomedical Analysis. Bologna, Italy. 30 June-3 July 2013

Lawson G, Cocks E. and Tanna S. (2013) Liquid chromatography-high resolution mass spectrometry applied to therapeutic drug monitoring using DBS sampling. Proceedings of The 24th International Symposium on Pharmaceutical and Biomedical Analysis. Bologna, Italy. 30 June-3 July 2013.

Tanna S, Cocks E. and Lawson G. (2013) Is the patient taking their 'heart' pills? A dried blood spot sample - LC-HRMS assay. Proceedings of The 24th International Symposium on Pharmaceutical and Biomedical Analysis. Bologna, Italy. 30 June-3 July 2013

Tanna S, Patel P, Mulla H. and Lawson G. (2011) Dried blood spot analysis to improve paediatric medication. Separation Science Asia. Singapore. 27-28 July 2011

Lawson G, Cocks E. and Tanna S. (2011) High resolution mass spectrometry for quantitative analysis of dried blood spots. Separation Science Asia. Singapore, 27-28 July 2011

Patel P, Pandya H, Spooner N, Della Pasque O, Gade S, Kairamknoda V, Lawson G, Tanna S, Mulla H. (2011) Dried blood spots and sparse sampling: A perfect combination for minimally invasive PK/PD studies in children. Population Approach Group Europe (PAGE) Meeting, Athens, Greece, June 2011

Tanna S, Cocks E and Lawson G. (2011) High resolution mass spectrometry for analysis of selected drugs in dried blood spots. 59th Conference on Mass Spectrometry and Allied Topics ASMS Meeting, Denver, Colorado, USA 5 – 9 June 2011

Lawson G, Mulla H, Patel P and Tanna S. (2011) Examples of dried blood spot sampling and analysis to improve paediatric medicine. 59th Conference on Mass Spectrometry and Allied Topics. ASMS Meeting, Denver, Colorado, USA 5-9 June 2011

Patel P, Lawson G, Tanna S, Mulla H. (2009) Facilitating paediatric PK studies: utility of the dried blood spot. Pharmacokinetics UK Conference, Birmingham UK, November 2009

Patel P, Lawson G, Mulla H and Tanna S. (2009) Applying dried blood spot analysis: the pathway to better paediatric care. Science @ BPC2009 Royal Pharmaceutical Society. Manchester Central, UK September 7-9 2009.

Lawson G, Pandya H, Mulla H and Tanna S. (2009) The use of blood spot analysis in paediatric care - From laboratory to bedside and back again. Science @ BPC2009 Royal Pharmaceutical Society. Manchester Central, UK. September 7-9 2009.

Lawson G, Coffey J, Titman C and Tanna S. (2009) Dried blood spot analyses by Ion Trap – Time of Flight Mass Spectrometry, the potential for improved child care? 18th Intl Mass Spectrometry Conference, PWA 427, Bremen, Germany Aug 30 – Sept 4 2009

Lawson G, Patel, P and Tanna S. The use of dried blood spot analysis in paediatric care – how mass spectrometry can direct child medication. 18th Intl Mass Spectrometry Conference, PMM 468, Bremen, Germany Aug 30 – Sept 4 2009

Tanna S, Lawson G Mulla H and Pandya H From laboratory to bedside and back again – The use of blood spot analysis in paediatric care. ACCP/ESCP International Congress on Clinical Pharmacy. Orange County Convention Centre, Orlando, Fl. USA. April 24 -28th.2009.

Key research outputs

  • Lawson,G, Cocks,E, Tanna,S. Determination of atenolol in dried blood spot samples by LC-HRMS: A potential method for assessing medication adherence. Journal of Chromatography B 2012; Manuscript accepted for publication
  • Lawson,G, Mulla,H, Tanna,S. Preliminary investigation of captopril in dried blood spots with liquid chromatography-mass spectrometry: A potential method for neonatal pharmacokinetic studies. Journal of Bioanalysis and Biomedicine 2012; Manuscript in press
  • Tanna,S, Lawson,G. Analytical methods used in conjunction with dried blood spots. Analytical Methods 2011; 3(8): 1709-1718
  • Mulla,H, Hussain,N, Tanna,S, Lawson,G, Manktelow,B N, Tuleu,C, Samani,
    N J, Pandy,H. Assessment of liquid captopril formulations used in children. Archives of Disease in Childhood 2011; 96(3): 293-296
  • Taylor,M J, Tanna,S, Sahota,T. In vivo study of a polymeric glucose sensitive insulin delivery system using a rat model. Journal of Pharmaceutical Sciences 2010; 99(10): 4215-4227
  • Patel,P, Tanna,S, Mulla,H, Kairamkonda,V, Pandya,H, Lawson,G. Dexamethasone quantification in dried blood spot samples using LC-MS: The potential for application to neonatal pharmacokinetic studies. Journal of Chromatography B 2010; 878: 3277-3282
  • Lawson,G, Anthony,D A and Crawford,D. The theory practice gap: ECMO research example. Paediatric Nursing 2008. 20(1): 41 – 45
  • Lawson,G, Jarvis,I, Flemming,M, Ramsden,D, Healey,M, Prior,T, Benton,D, Ing,H, Chamberland,M, Huttunen,J, Ratajczak,P, de Miscault,J-C, Roa,V, Andrews,R, Inrig,L, Bartosz,E and Carter,J. Final Report NATO UNCLASSIFIED – PFP(NIAG)D(2008)0002. NIAG SG112 – Stand-off Detection Technologies for Radiological Threats. 2008

Recent national media coverage of DBS research conducted by Sangeeta Tanna and Graham Lawson
The pioneering use of dried blood spot methods to monitor prescription compliance among patients taking cardiovascular medications was the subject of media coverage in September 2011. This included television coverage on BBC national and local news in addition to a live BBC Radio Leicester interview. 

DBS research on front cover of international journal, Analytical Methods

The front cover of the Royal Society of Chemistry (RSC) journal – Analytical Methods (Vol 3: Issue 8 August 2011) is devoted to the research of Sangeeta Tanna and Graham Lawson into the benefits that can be derived from the analysis of dried blood spots (DBS). This is now referred to by the RSC as ‘The Happy Cover’.

Current research students

4 PhD students

Externally funded research grants information

  • Stand off detection techniques for residual radiation. 2007/8 Contract value £18,000.
  • NATO Advanced studies research group. NIAG, UK Expert in Low level radiation detection.
  • Collaborators from NATO Industry and Military.
  • Micro analytical techniques for PK studies in infants. 2007- 9. £69,800. CI (with Dr S. Tanna PI) .
  • NHS NEAT (now i4i) Funding Investigation of dried blood spot analysis for child medicine applications. 2008-2011 UHL NHS Trust consumables funding . £21,000.
  • Assessment of liquid captopril formulations used in children. 2008-9 NHS Research for Patient Benefit Funding. Joint research with UHL NHS Trust. Role CI with Dr S Tanna. Collaborators UHL NHS Trust.
  • NIAG SG112 – Stand-off Detection Technologies for Radiological Threats. 1 April 2008.

Internally funded research project information

  • Investigation of dried blood spot analysis for paediatric clinical applications. DMU PhD Student Bursary PI and Ist supervisor. Collaborators UHL NHS Trust, Sheffield Children’s Hospital, GSK plc. 2008-2011.Contract £40,500.
  • Tandem Mass spectrometry analyses of dried blood spots. 2010-2013 Contract £296,000. Role PI (with Dr S Tanna CI) DMU RIF Funded.
  • Tandem Mass Spectrometry Project. Contract £30,000. Role PI (with Dr S Tanna CI) DMU HEIF Funded.

Case studies

1.The blood spot analysis research and its potential impact on improving healthcare received extensive media coverage during a British Council sponsored visit to Chongqing, China in April 2012. It was widely covered by 20 national and local media, including CCTV, Chongqing TV, Xinhua News Agency, Guang Ming Daily People’s Daily, HongKong Wenhui Po, people.com.cn, CQ.QQ.com etc. The link below is Chongqing TV’s coverage of the event at its satellite news programme.
http://v.youku.com/v_show/id_XMzg3Nzg2OTk2.html|

2. In September 2011 the pioneering use of dried blood spot methods to monitor prescription compliance among patients taking cardiovascular medications was the subject of local and national media coverage. This included television coverage on BBC national and local news in addition to a live BBC Radio Leicester interview. It was featured on the BBC news website at: http://www.bbc.co.uk/news/uk-england-leicestershire-15002237|

3. The following was published in the Leicester Mercury of Saturday, August 21, 2010:
http://www.thisisleicestershire.co.uk/news/Baby-test-team-win-award/article-2552713-detail/article.html|

Baby test team win top award

A test pioneered by De Montfort University| experts, which could help improve care and treatment of sick newborn babies, has won a top award.

The Royal Society of Chemistry Analytical Methods Prize 2010 was awarded to Dr Sangeeta Tanna and Dr Graham Lawson for their work.

The test measures how much of a drug is in a baby's blood from a single drop and will allow medics to treat them more effectively.

It could help revolutionise how drugs are used to treat critically-ill newborn babies.

Graham Lawson

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