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Dr Dritan Hasa

Job: VC2020 Lecturer in Pharmaceutics

Faculty: Health and Life Sciences

School/department: Leicester School of Pharmacy

Address: De Montfort University, The Gateway, Leicester, LE1 9BH

T: 0116 257 7893

E: dritan.hasa@dmu.ac.uk

W:

 

Personal profile

Dr. Dritan Hasa joined Leicester School of Pharmacy as a VC2020 Lecturer in Pharmaceutics.

He graduated in Pharmaceutical Chemistry and Technology at the University of Trieste (Italy), and obtained his PhD based on the study of mechanochemically-induced defects in molecular crystals and stabilisation of metastable structures using polymeric excipients. He also investigated the possibility to tailor controlled-released solid forms by producing unconventional helical and laminar-shaped extrudates. Upon graduation, He spent one year working in a project that involved industrial partners. Subsequently, Dr. Hasa moved at the University of Cambridge (UK) where He developed a keen interest on the understanding of the mechanisms that govern solid-state reactions and phase transitions in crystalline solids with particular attention to cocrystals.

His current research focuses on the use of mechanochemical technologies such as ball milling and hot melt extrusion for the preparation of functional pharmaceutical materials. This is an exciting time for such green technologies: vast progress has been made in the last three decades, especially in academic research, and new areas of applications will soon impact substantially in real world applications.

Dr Hasa has a keen interest on finding new applications for pharmaceutical polymeric materials. He also performs fundamental research at issues surrounding all aspects of crystallization and polymorphism in single and multicomponent materials. The objective is to gain more knowledge on possible connections and/or differences between the solid-state and solution mechanisms of crystallization.

Key research outputs

  • Hasa D., Miniussi E., Jones W. Mechanochemical synthesis of multicomponent crystals: one liquid for one polymorph? A myth to dispel. Cryst. Growth Des. 16, 4582−4588, 2016, http://pubs.acs.org/doi/abs/10.1021/acs.cgd.6b00682
  • Hasa D., Schneider Rauber G., Voinovich D., Jones W. Cocrystal formation through mechanochemistry: from neat and liquid-assisted Grinding to polymer-assisted grinding. Angew. Chem. Int. Ed. 54, 7371-7375, 2015, http://onlinelibrary.wiley.com/doi/10.1002/anie.201501638/full
  • Hasa D., Perissutti B., Campisi B., Grassi M., Grabnar I., Golob S., Mian M., Voinovich D. Quality-oriented optimization of melt extruded laminar systems using mixture experimental design. Eur. J. Pharm. Sci. 75, 169-176, 2015. http://www.sciencedirect.com/science/article/pii/S0928098715001566
  • Hasa D., Perissutti B., Cepek C., Bhardwaj S., Carlino E., Grassi M., Invernizzi S., Voinovich D. Drug salt formation via mechanochemistry: The case study of vincamine. Mol. Pharm. 10, 211-224, 2013. http://pubs.acs.org/doi/abs/10.1021/mp300371f
  • Hasa D., Voinovich D., Perissutti B., Bonifacio A., Grassi M., Franceschinis E., Dall’Acqua S., Speh M., Plavec J., Invernizzi S. Multidisciplinary approach on characterizing a Mechanochemically activated composite of Vinpocetine and Crospovidone. J.Pharm. Sci. 100, 915-932, 2011. http://onlinelibrary.wiley.com/doi/10.1002/jps.22331/full

Research interests/expertise

  • Green manufacturing of pharmaceutical solids
  • Ball milling
  • Extrusion technologies
  • Cocrystal engineering
  • Polymorphism
  • Amorphous solid form dosages
  • Advanced characterisation techniques for solids
  • Polymer properties and applications
  • Self-emulsifying systems 
  • Postdoctoral research associate

  • University of Cambridge (UK), November 2015 - November 2016
  • Postdoctoral research associate
  • University of Cambridge (UK), May 2014 - April 2015
  • Postdoctoral researcher
  • University of Trieste (Italy), May 2013 - April 2014

Qualifications

  • PhD in Chemical and Pharmaceutical Science and Technology
  • University of Trieste (Italy), January 2010 - April 2013
  • MSc in Pharmaceutical Chemistry and Technology
  • University of Trieste (Italy), September 2004 - July 2009 

Conference attendance

  • Nucleation - A Transition State to the Directed Assembly of Materials Faraday Discussion, Leeds (UK), 30 March-1 April 2015, Understanding the mechanochemical pathways of cocrystal formation and polymorphism, Hasa D., Jones W, Poster (presenting author).

  • Molecular materials: from fundamentals to applications, Novosibirsk (Russia) 9-13 February 2015, Cocrystal interconversion via mechanochemistry: a study of Caffeine-Anthranilic acid, Hasa D., Jones W, Poster (presenting author).

  • Italian National Doctoral School in Pharmaceutical Technologies, 10-13 September, 2012, Florence, Italy, Mechanochemical salt formation of vincamine, Hasa D., Perissutti B., Grassi M., Kleinebudde P., Voinovich D, Oral Presentation (Presenting author).

  • 9th Central Euro Symposium on Pharmaceutical Technology with focus on Nanopharmaceuticals and Nanomedicine, Dubrovnik (Croatia) 20-22 September 2012, Oral bioavailability of Vincamine coground nanocomposites with linear polymer, Hasa D., Perissutti B., Grassi M., Chierotti M.R., Gobetto R., Grabnar I., Voinovich D, Poster (presenting author).

  • 9th Central Euro Symposium on Pharmaceutical Technology with focus on Nanopharmaceuticals and Nanomedicine, Dubrovnik (Croatia) 20-22 September 2012, Red rice extract solid self nano-emulsifying systems improve lovastatin oral bioavailability, Franceschinis E., Hasa D., Trotter A., Dall’acqua S., Realdon N, Poster (presenting author).

  • Twenty-first meeting of the Population Approach Group in Europe, Venice (Italy) 5-8 June 2012, Enterohepatic recirculation of free and conjugated silybin following administration of a chewing gum with Milk Thistle Extract, Grabnar I., Pislar M., Maggi L., Hasa D., Voinovich D, Poster  

  • 4th BBBB, Bled International Conference On Pharmaceutical Sciences, Bled (Slovenia) 29 September-1 October 2011, Enhancing oral bioavailability of vinpocetine through mechanochemical citrate salt formation, Hasa D., Voinovich D., Perissutti B., Grassi M., Bhardwaj S., Chierotti M.R., Gobetto R, Poster (presenting author).

  • 8th Central European Symposium on Pharmaceutical Technology and Biodelivery Systems, Graz (Austria), 16-18 September 2010, Multidisciplinary approach on characterizing composites of vinpocetine and crospovidone obtained by solid state activation, Hasa D., Voinovich D., Perissutti B., Bonifacio A., Grassi M., Franceschinis E., Dall’Acqua S., Speh M., Plavec J, Poster (presenting author)

  • 8th Central European Symposium on Pharmaceutical Technology and Biodelivery Systems, Graz (Austria), 16-18 September 2010, Calogera’ G., Passerini N., Albertini B., Hasa D., Voinovich D. Melt Granulation in fluidized bed: Screening of the process variables by factorial design, Poster (presenting author) 

Professional esteem indicators

  • Crystal Growth and Design (ACS)
  • CrystEngComm (RSC)
  • Pharmaceutical Research (Springer)
  • European Journal of Pharmaceutical Sciences (Elsevier)
  • EJPB (Elsevier)

Case studies

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