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Dr Chris Young

Job: Early Career Academic Fellow VC2020

School/department: School of Allied Health Sciences

Address: De Montfort University, The Gateway, Leicester, LE1 9BH

T: +44 (0)0116 207 8166

E: chris.young@dmu.ac.uk

W: https://www.researchgate.net/profile/Chris_Young8

 

Personal profile

Dr. Young is a Vice Chancellor’s Early Career Fellow in the School of Allied Health Sciences at DMU. He completed his PhD in molecular medicine at the University of Portsmouth in the lab of Professor Darek Gorecki, where he investigated purinergic signalling responses in dystrophic muscle-immune interactions. His postdoctoral work, also at Portsmouth, expanded this new field, which now approaches clinical trials.

Dr Young has interests in skeletal muscle cell culture models; he intends to generate new in-vitro models of muscle atrophy, injury & aging at DMU. His research seeks novel insight into the molecular mechanisms underlying these phenomena, which could lead to new treatments, therapeutics & supplements to improve human health and longevity.

Research group affiliations

  • Cell Signalling
  • Biomedical & Environmental Health
  • Medicinal Chemistry
  • Pharmacology
  • Pharmaceutical Technologies

Key research outputs

  • Young, C.N.J., Chira, N., Al-Khalidi, Chan, P., Vaudry, D., R., Zablocki, K., Gorecki, D. (2017). Sustained activation of P2X7 induces MMP-2-evoked cleavage and functional purinoceptor inhibition. Journal of Molecular Cell Biology (in press).
     
  • Young, C.N.J., Sinadinos, A., Lefebvre, A., Chan, P., Arkle, D., Vaudry, D., Gorecki, D. (2015). A novel mechanism of autophagic cell death in dystrophic muscles via P2RX7 receptor large pore formation and Hsp90. Autophagy. 11(1):113-130.
     
  • Sinadinos, A., Young, C.N.J., Al-Khalidi, R., Teti, A., Kalinski, P., Mohamad, S., Floriot, L., Henry, T., Tozzi, G., Jiang, T., Wurtz, O., Lefebvre, A., Tong, J., Vaudry, D., Arkle, S., doRego, JC., Gorecki, D. (2015). P2X7 purinoceptor ablation ameliorates muscle and non-muscle pathology in the mdx mouse model of Duchenne muscular dystrophy. PLOS Medicine.12(10): e1001888. 

Research interests/expertise

  • Skeletal muscle models; molecular mechanisms of exercise physiology, pathology & aging.
  • Autophagy signalling in skeletal muscle; growth & maintenance of muscle mass.
  • Skeletal muscle-immune interactions.
  • Ectopic calcium formation in skeletal muscle in response to injury & disease.
  • P2X7 receptor signalling; P2X7 large pore formation and function, P2X7-autophagy signalling, P2X7 large pore formation as a novel therapeutic target in cancer.     

Areas of teaching

  • Chemistry for the Biosciences
  • Biochemistry and Molecular Cell Biology
  • Cyto & Histopathology
  • Clinical Biochemistry
  • Clinical Genetics
  • Cancer Biology

Qualifications

  • 2007-2011 PhD, Molecular Medicine, University of Portsmouth, UK

  • 2006-2007 MSc, Genetic Manipulation and Molecular Cell Biology (Distinction), University of Sussex, UK

  • 2003-2006 BSc, Biochemistry and Organic Chemistry (First Class Honours), The Open University

Courses taught

  • BSc Biomedical Science

Membership of professional associations and societies

  • Member of the Biochemical Society

Conference attendance

Current research students

  • PhD student, Natalia Chira

Professional esteem indicators

  • Reviewer for the Journal of Cellular Physiology & Biochemistry
Chris Young profile pic (002)

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